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U2383

Ubiquitin Carrier Protein H3/CDC34 human

≥95% (SDS-PAGE), recombinant, expressed in E. coli overproducing strain

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100 μg
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$532.00

About This Item

UNSPSC Code:
12352202
NACRES:
NA.56
MDL number:
MFCD03101856
Form:
solution
Assay:
≥95% (SDS-PAGE)
Biological source:
human
Recombinant:
expressed in E. coli overproducing strain
Mol wt:
~32 kDa

$532.00

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biological source

human

Quality Segment

200

recombinant

expressed in E. coli overproducing strain

assay

≥95% (SDS-PAGE)

form

solution

mol wt

~32 kDa

UniProt accession no.

P49427, P61088

application(s)

cell analysis

shipped in

dry ice

storage temp.

−70°C

Gene Information

human ... CDC34(997), UBE2N(7334)

Biochem/physiol Actions

Infected cell protein 0 of herpes simplex virus 1 was shown to bind UbcH3 and induce its degradation by promoting its polyubiquination. This resulted in increased expression of an UbcH3-target gene cyclin D1 and aided in further viral infection.
Cdc34 is an essential gene for viability in yeast. Cdc34 mediates the transition from G1 to S-phase of the cell cycle by degrading the S-phase cyclin/CDK inhibitor, SIC1 in yeast and p27(KIP1) in human. Cdc34 is also known to interact with the Skp1/Cdc53/F-box (SCF) ubiquitin ligase subunits Cul1 to degrade the NF-κB inhibitor IκBα in a phosphorylation-dependent manner.

Physical form

Solution in 50 mM HEPES, 200 mM NaCl, 1 mM TCEP (pH 7.5), and 10% glycerol.

Other Notes

Manufactured for Sigma by Boston Biochem. Inc.

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Ubiquitin Carrier Protein H3/CDC34 human ≥95% (SDS-PAGE), recombinant, expressed in E. coli overproducing strain

Sigma-Aldrich

U2383

Ubiquitin Carrier Protein H3/CDC34 human

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Sigma-Aldrich

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Sigma-Aldrich

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Ubiquitin-Carrier Protein H7 human ≥95% (SDS-PAGE), recombinant, expressed in E. coli, liquid

Sigma-Aldrich

U9132

Ubiquitin-Carrier Protein H7 human

description

≥95% (SDS-PAGE), recombinant, expressed in E. coli overproducing strain

description

-

description

recombinant, expressed in E. coli, ≥70% (SDS-PAGE)

description

≥95% (SDS-PAGE), recombinant, expressed in E. coli, liquid

biological source

human

biological source

human

biological source

human

biological source

-

assay

≥95% (SDS-PAGE)

assay

>95% (SDS-PAGE)

assay

≥70% (SDS-PAGE)

assay

≥95% (SDS-PAGE)

recombinant

expressed in E. coli overproducing strain

recombinant

expressed in E. coli (GST-tagged)

recombinant

expressed in E. coli

recombinant

expressed in E. coli

form

solution

form

solution

form

aqueous solution

form

liquid

mol wt

~32 kDa

mol wt

~14 kDa

mol wt

32 kDa

mol wt

18 kDa

UniProt accession no.

P49427, P61088

UniProt accession no.

P61088, P62256

UniProt accession no.

P68431

UniProt accession no.

P60604, P68036

Storage Class

12 - Non Combustible Liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

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