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U5377

Uracil 1-β-D-arabinofuranoside

≥98% (HPLC), synthetic (organic), powder

Synonym(s):

Arauridine, Spongouridin, 1-β-D-Arabinofuranosyluracil

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Size/SKUAvailabilityPrice
250 mg

Available to ship TODAYfromMILWAUKEE

$579.00

About This Item

Empirical Formula (Hill Notation):
C9H12N2O6
CAS Number:
3083-77-0
Molecular Weight:
244.20
NACRES:
NA.51
PubChem Substance ID:
24900655
UNSPSC Code:
41106305
EC Number:
221-386-9
MDL number:
MFCD00065998
Beilstein/REAXYS Number:
28749
Assay:
≥98% (HPLC)
Biological source:
synthetic (organic)
Form:
powder
Solubility:
water: 50 mg/mL, clear, colorless
Storage temp.:
−20°C

$579.00

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Product Name

Uracil 1-β-D-arabinofuranoside, lymphoma antiproliferative

biological source

synthetic (organic)

Quality Segment

assay

≥98% (HPLC)

form

powder

solubility

water: 50 mg/mL, clear, colorless

storage temp.

−20°C

SMILES string

OC[C@H]1O[C@H]([C@@H](O)[C@@H]1O)N2C=CC(=O)NC2=O

InChI

1S/C9H12N2O6/c12-3-4-6(14)7(15)8(17-4)11-2-1-5(13)10-9(11)16/h1-2,4,6-8,12,14-15H,3H2,(H,10,13,16)/t4-,6-,7+,8-/m1/s1

InChI key

DRTQHJPVMGBUCF-CCXZUQQUSA-N

General description

1-β-d-arabinofuranosyluracil (Ara-U) is the detoxification product or metabolite of 1-β-d-arabinofuranosylcytosine (Ara-C). Uracil 1-β-D-arabinofuranoside is the human metabolite of a cytostatic agent called cytarabine (CYT).

Application

Uracil 1-β-D-arabinofuranoside may be used as a reference compound in the analysis of cytostatics and metabolites in hospital wastewater by hydrophilic interaction chromatography/tandem mass spectrometry to demonstrate its analytical possibilities and limitations. It may also be used as a standard for chemical analysis to investigate the ecotoxicity and genotoxicity of cytotoxic antineoplastic drugs, like cytarabine (CYT) and their metabolites, like uracil-1-β-d-arabinofuranoside (AraU).

Biochem/physiol Actions

1-β-D-Arabinofuranosyluracil (ara-U) is capable of inhibiting proliferation of L5178Y mouse lymphoma cells at 17 μM concentration.

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This Item
PHR32601705800U0100000
Uracil 1-β-D-arabinofuranoside lymphoma antiproliferative

Sigma-Aldrich

U5377

Uracil 1-β-D-arabinofuranoside

Uracil Arabinoside pharmaceutical secondary standard, certified reference material

Supelco

PHR3260

Uracil Arabinoside

Uracil arabinoside United States Pharmacopeia (USP) Reference Standard

USP

1705800

Uracil arabinoside

Uracil arabinoside European Pharmacopoeia (EP) Reference Standard

U0100000

Uracil arabinoside

description

lymphoma antiproliferative

description

pharmaceutical secondary standard, certified reference material

description

United States Pharmacopeia (USP) Reference Standard

description

European Pharmacopoeia (EP) Reference Standard

biological source

synthetic (organic)

biological source

-

biological source

-

biological source

-

Quality Level

200

Quality Level

300

Quality Level

-

Quality Level

-

form

powder

form

-

form

-

form

-

assay

≥98% (HPLC)

assay

-

assay

-

assay

-

solubility

water: 50 mg/mL, clear, colorless

solubility

-

solubility

-

solubility

-

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

PPE (personal protective equipment)

Eyeshields, Gloves, type N95 (US)

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