Skip to Content
MilliporeSigma

Skip To

U6508

UCN-01

≥97% (HPLC), PKC inhibitor, powder

Synonym(s):

KW-2401

Sign In to View Organizational & Contract Pricing.

Select a Size

Change View
Size/SKUAvailabilityPrice
1 mg
Check Cart for Availability
$251.00
5 mg
Check Cart for Availability
$986.00

About This Item

Empirical Formula (Hill Notation):
C28H26N4O4
CAS Number:
Molecular Weight:
482.53
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Assay:
≥97% (HPLC)
Form:
powder
Storage condition:
protect from light

$251.00


Check Cart for Availability

Request a Custom Order
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist


Product Name

UCN-01, ≥97% (HPLC), powder

Quality Segment

assay

≥97% (HPLC)

form

powder

optical activity

[α]20/D 130 to 160°, c = 0.2 in DMSO

storage condition

protect from light

color

light yellow

solubility

DMSO: >5 mg/mL, H2O: insoluble

storage temp.

2-8°C

SMILES string

[H][C@@]1(C[C@@H](NC)[C@H]2OC)N3C4=C(N([C@@]2(C)O1)C5=C6C=CC=C5)C6=C7C(C(N[C@@H]7O)=O)=C4C8=C3C=CC=C8

InChI

1S/C28H26N4O4/c1-28-25(35-3)15(29-2)12-18(36-28)31-16-10-6-4-8-13(16)19-21-22(27(34)30-26(21)33)20-14-9-5-7-11-17(14)32(28)24(20)23(19)31/h4-11,15,18,25,27,29,34H,12H2,1-3H3,(H,30,33)/t15-,18-,25-,27-,28+/m1/s1

InChI key

PBCZSGKMGDDXIJ-HQCWYSJUSA-N

Application

UCN-01 has been used to study checkpoint kinase-1 (CHK1) protein function in trophoblast stem (TS) cells. It has also been used to study UV-induced CHK1 phosphorylation in IB10 cells.

Biochem/physiol Actions

UCN-01 is a selective inhibitor for conventional PKC isotypes over novel PKC isotypes.

Features and Benefits

This compound is featured on the PKB/Akt and PKC pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Preparation Note

UCN-01 is soluble in DMSO at a concentration that is greater than 5 mg/ml. However, it is insoluble in water.

Compare Similar Items

View Full Comparison

Show Differences

1 of 1

This Item
539644SML1858SML0699
description

≥97% (HPLC), powder

description

A cell-permeable Staurosporine derived anticancer agent that reversibly and ATP-competitively inhibits several protein kinases.

description

≥98% (HPLC)

description

≥97% (HPLC)

form

powder

form

solid

form

powder

form

lyophilized powder

assay

≥97% (HPLC)

assay

≥95% (HPLC)

assay

≥98% (HPLC)

assay

≥97% (HPLC)

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage condition

protect from light

storage condition

OK to freeze, protect from light

storage condition

-

storage condition

protect from light

solubility

DMSO: >5 mg/mL, H2O: insoluble

solubility

ethanol: 1 mg/mL, DMSO: 5 mg/mL

solubility

DMSO: 20 mg/mL, clear

solubility

DMSO: 5 mg/mL, clear (warmed)


Still not finding the right product?

Explore all of our products under UCN-01


Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable



Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

It looks like we've run into a problem, but you can still download Certificates of Analysis from our Documents section.

If you need assistance, please contact Customer Support

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library



Questions

Reviews

No rating value

Active Filters