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Anti-Vascular Endothelial Growth Factor Receptor 2 antibody produced in goat

Name: Anti-Vascular Endothelial Growth Factor Receptor 2 antibody produced in goat
Brand: SIGMA
Price: 551.65 USD
Availability: InStock

affinity isolated antibody, lyophilized powder

Synonym(s):

Anti-Flk-1, Anti-VEGF R2

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Size/SKU	Availability	Price
100 μg	Available to ship TODAYfromMILWAUKEE	$649.00 $551.65

About This Item

UNSPSC Code:

51111800

NACRES:

NA.41

MDL number:

MFCD01092518

Conjugate:

unconjugated

Clone:

polyclonal

Application:

FACS, IHC, Neutral, WB

Citations:

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Properties

biological source

goat

Quality Segment

200

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

lyophilized powder

species reactivity

mouse

technique(s)

flow cytometry: 3-10 μg/mL (10⁶ cells), immunohistochemistry: 5-15 μg/mL using cells and tissues, neutralization: suitable, western blot: 0.1-0.2 μg/mL

UniProt accession no.

P35918

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

mouse ... Kdr(16542)

Description

General description

Vascular endothelial growth factors receptors (VEGF Rs) are receptor tyrosine kinases that bind to VEGF that plays important role in embryonic vasculogenesis, angiogenesis and homeostasis. VEGF R2 has the ability to form heterodimers with VEGF R1 and VEGF R3. The binding of VEGF to VEGF R2 results in activation of tyrosine amino acids of the cytoplasmic tail of the receptor. This interaction results in the activation of MAPK, PI3K, PKC, FAK and Src kinase pathways. The biological roles of VEGF R2 include in epithelial cell growth, proliferation, survival, migration and vascular permeability and angiogenesis. Due to its role in promoting migration and angiogenesis, VEGF R2 has been implicated in breast and prostate cancer
Anti-Vascular Endothelial Growth Factor Receptor-2 recognizes mouse VEGF R2.

Immunogen

purified recombinant mouse VEGF R2 extracellular domain expressed in NSO cells.

Application

Anti-Vascular Endothelial Growth Factor Receptor 2 antibody may be used in immunoblotting at a working concentration of 0.1-0.2 μg/ml. For flow cytometry the recommended concentration is 3-10 μg/ml. The immunohistochemistry of cells and tissues, a working concentration of 5-15 μg/ml may be used. For neutralization reactions, ND50 of 0.1-0.3 μg/ml is recommended.

Biochem/physiol Actions

The antibody has the ability to neutralize the biological activity of recombinant mouse VEGF R2. It demonstates approximately 40% cross-reactivity with recombinant human VEGF R2, 2% cross-reactivty with recombinant mouse VEGF R1, and no cross-reactivity with recombinant human VEGF R1 and VEGF R3.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing carbohydrates.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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This Item	V1253	V9134	B0555
Sigma-Aldrich V1014 Anti-Vascular Endothelial Growth Factor Receptor 2 antibody produced in goat	Sigma-Aldrich V1253 Anti-Vascular Endothelial Growth Factor antibody produced in goat	Sigma-Aldrich V9134 Monoclonal Anti-Vascular Endothelial Growth Factor Receptor-2 antibody produced in mouse	Sigma-Aldrich B0555 Anti-Vascular Endothelial Growth Factor Receptor-2 (KDR)−Biotin Conjugate antibody, Mouse monoclonal
description affinity isolated antibody, lyophilized powder	description affinity isolated antibody, lyophilized powder	description clone KDR-1, ascites fluid	description clone 260.4, KDR-2, purified from hybridoma cell culture
antibody form affinity isolated antibody	antibody form affinity isolated antibody	antibody form ascites fluid	antibody form purified from hybridoma cell culture
Quality Level 200	Quality Level 100	Quality Level 200	Quality Level 200
biological source goat	biological source goat	biological source mouse	biological source mouse
conjugate unconjugated	conjugate unconjugated	conjugate unconjugated	conjugate biotin conjugate
Gene Information mouse ... Kdr(16542)	Gene Information mouse ... Vegfa(22339)	Gene Information human ... KDR(3791)	Gene Information human ... KDR(3791)
clone polyclonal	clone polyclonal	clone KDR-1, monoclonal	clone 260.4, KDR-2, monoclonal

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Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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