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V106

R(+)-Verapamil monohydrochloride hydrate

≥98% (HPLC), powder

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5 mg

Available to ship TODAY

$307.00
25 mg

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$1,160.00

About This Item

Empirical Formula (Hill Notation):
C27H38N2O4 · HCl · xH2O
CAS Number:
38176-02-2
Molecular Weight:
491.06 (anhydrous basis)
NACRES:
NA.77
PubChem Substance ID:
24900706
UNSPSC Code:
12161501
EC Number:
205-800-5
MDL number:
MFCD11046028
Assay:
≥98% (HPLC)
Form:
powder
Storage condition:
desiccated

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Quality Segment

assay

≥98% (HPLC)

form

powder

optical activity

[α]22/D +9.6°, c = 0.5 in ethanol(lit.)

storage condition

desiccated

color

white

solubility

H2O: >30 mg/mL, ethanol: soluble

SMILES string

O.Cl.COc1ccc(CCN(C)CCC[C@@](C#N)(C(C)C)c2ccc(OC)c(OC)c2)cc1OC

InChI

1S/C27H38N2O4.ClH.H2O/c1-20(2)27(19-28,22-10-12-24(31-5)26(18-22)33-7)14-8-15-29(3)16-13-21-9-11-23(30-4)25(17-21)32-6;;/h9-12,17-18,20H,8,13-16H2,1-7H3;1H;1H2/t27-;;/m1../s1

InChI key

ICKXRKHJKXMFLR-KFSCGDPASA-N

Application

R(+)-Verapamil monohydrochloride hydrate has been used as a P-glycoprotein (gp) inhibitor, to detect P-gp expression on the SK-OV-3 and SK-OV-3/DDP cell surface by flow cytometry. It has also been used as a calcium channel blocker, to evaluate its effect on doxorubicin (DOX) cytotoxicity.

Biochem/physiol Actions

Inhibitor of P-glycoprotein; less active enantiomer of (±)-verapamil.
Verapamil is a calcium channel blocker. Verapamil hydrochloride is a phenyl-alkyl amine derivative and is potentially used for treating hypertension, angina pectoris and arrhythmias. It is water soluble in nature.

Disclaimer

hygroscopic

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This Item
1711202V0100000PHR1131
R(+)-Verapamil monohydrochloride hydrate ≥98% (HPLC), powder

Sigma-Aldrich

V106

R(+)-Verapamil monohydrochloride hydrate

Verapamil hydrochloride United States Pharmacopeia (USP) Reference Standard

USP

1711202

Verapamil hydrochloride

Verapamil hydrochloride European Pharmacopoeia (EP) Reference Standard

V0100000

Verapamil hydrochloride

(±)-Verapamil hydrochloride Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1131

(±)-Verapamil hydrochloride

description

≥98% (HPLC), powder

description

United States Pharmacopeia (USP) Reference Standard

description

European Pharmacopoeia (EP) Reference Standard

description

Pharmaceutical Secondary Standard; Certified Reference Material

assay

≥98% (HPLC)

assay

-

assay

-

assay

-

form

powder

form

-

form

-

form

-

Quality Level

100

Quality Level

-

Quality Level

-

Quality Level

300

solubility

H2O: >30 mg/mL, ethanol: soluble

solubility

-

solubility

-

solubility

-

storage condition

desiccated

storage condition

-

storage condition

-

storage condition

-

color

white

color

-

color

-

color

-

Pictograms

Skull and crossbones
GHS06

Signal Word

Danger

Hazard Codes

H301 + H311 + H331

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

PPE (personal protective equipment)

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

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