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Anti-VGLUT2 (HY-19) antibody produced in rabbit

Name: Anti-VGLUT2 (HY-19) antibody produced in rabbit
Brand: SIGMA
Price: 650 USD
Availability: InStock

IgG fraction of antiserum, buffered aqueous solution

Synonym(s):

Anti-DNPI, Anti-VGLUT2

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Size/SKU	Availability	Price
200 μL	Check Cart for Availability	$650.00

About This Item

UNSPSC Code:

12352203

NACRES:

NA.41

MDL number:

MFCD05865393

Conjugate:

unconjugated

Clone:

polyclonal

Application:

Citations:

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Properties

biological source

rabbit

Quality Segment

200

conjugate

unconjugated

antibody form

IgG fraction of antiserum

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 65 kDa

species reactivity

rat

technique(s)

western blot: 1:2,000 using synaptic vesicle (SV) fraction of rat brain

UniProt accession no.

Q9JI12

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... SLC17A6(57084)
mouse ... Slc17a6(140919)
rat ... Slc17a6(84487)

Description

General description

Vesicular glutamate transporter 2 (vGluT2), also known as solute carrier family 17 member 6 (SLC17A6), is encoded by the gene mapped to human chromosome 11p14.3. The encoded protein belongs to the SLC17 family of transporters. vGluT2 is an integral membrane protein with 12 predicted transmembrane domains. It is localized on synaptic vesicles and is expressed mainly in neurons and endocrine terminals.

Immunogen

synthetic peptide located near the C-terminus of rat VGLUT2 (amino acids 520-538). The sequence is identical in mouse and human VGLUT2 and has no homology to VGLUT1.

Application

Anti-VGLUT2 (HY-19) antibody produced in rabbit has been used in:

western blot
immunolabelling.
immunohistochemistry.

Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunofluorescence (1 paper)

Biochem/physiol Actions

Vesicular glutamate transporters (vGluT) play a vital role in the transport of glutamate into secretory vesicles. They are also used as a specific markers to recognize glutamatergic neurons. vGluT2 is considered to be a potent target for reducing glutamatergic neurotransmission. Thus, vGluT2 could be useful for the treatment of neurodegenerative diseases in which chronic excessive glutamate signaling has been involved. It is also used for treating epilepsy and pain.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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This Item	SAB5200258	SAB5200276	MAB5504
$Anti-VGLUT2 (HY-19) antibody produced in rabbit IgG fraction of antiserum, buffered aqueous solution$ Sigma-Aldrich V2514 Anti-VGLUT2 (HY-19) antibody produced in rabbit	Sigma-Aldrich SAB5200258 Monoclonal Anti-Vglut1 antibody produced in mouse	Sigma-Aldrich SAB5200276 Monoclonal Anti-Vglut2 antibody produced in mouse	Sigma-Aldrich MAB5504 Anti-Vesicular Glutamate Transporter 2 Antibody
description IgG fraction of antiserum, buffered aqueous solution	description clone S28-9, purified immunoglobulin	description clone S29-29, purified immunoglobulin	description clone 8G9.2, Chemicon^®, from mouse
biological source rabbit	biological source mouse	biological source mouse	biological source mouse
antibody form IgG fraction of antiserum	antibody form purified immunoglobulin	antibody form purified immunoglobulin	antibody form purified antibody
Quality Level 200	Quality Level 100	Quality Level 100	Quality Level 100
conjugate unconjugated	conjugate unconjugated	conjugate unconjugated	conjugate unconjugated
clone polyclonal	clone S28-9, monoclonal	clone S29-29, monoclonal	clone 8G9.2, monoclonal
species reactivity rat	species reactivity rat, human, mouse	species reactivity human, mouse, rat	species reactivity mouse, rat

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Storage Class

10 - Combustible liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

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