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V3501

Vitamin K1

viscous liquid

Synonym(s):

2-Methyl-3-phytyl-1,4-naphthoquinone, 3-Phytylmenadione, Phylloquinone, Vitamin K1(20)

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Pack SizeSKUAvailabilityPrice
1 g
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$149.00
5 g
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$413.00
10 g

Estimated to ship onJuly 27, 2026fromMILWAUKEE

$709.00

About This Item

Empirical Formula (Hill Notation):
C31H46O2
CAS Number:
84-80-0
Molecular Weight:
450.70
NACRES:
NA.28
PubChem Substance ID:
24900741
eCl@ss:
34058015
UNSPSC Code:
12352205
EC Number:
201-564-2
MDL number:
MFCD00214063
Beilstein/REAXYS Number:
2568816

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biological source

synthetic (organic
inorganic)

Quality Level

100

form

viscous liquid

color

, Yellow to Very Dark Yellow to Very Dark Orange

refractive index

n20/D 1.527 (lit.)

mp

−20 °C (lit.)

density

0.984 g/mL at 25 °C (lit.)

storage temp.

2-8°C

SMILES string

O=C(C1=CC=CC=C21)C(C)=C(C/C=C(CCC[C@@H](CCC[C@H](C)CCCC(C)C)C)\C)C2=O

InChI

1S/C31H46O2/c1-22(2)12-9-13-23(3)14-10-15-24(4)16-11-17-25(5)20-21-27-26(6)30(32)28-18-7-8-19-29(28)31(27)33/h7-8,18-20,22-24H,9-17,21H2,1-6H3/b25-20+/t23-,24-/m1/s1

InChI key

MBWXNTAXLNYFJB-NKFFZRIASA-N

General description

Vitamin K1/Phylloquinone is a prenylated naphthoquinone. It is produced by plants, green algae and some species of cyanobacteria.

Application

Vitamin K1 has been used in the preparation of culture media.

Biochem/physiol Actions

Vitamin K1 (Phylloquinone) is a lipid soluble polycyclic aromatic ketone used as a cofactor in the formation of coagulation factors II (prothrombin), VII, IX and X; anticoagulant factors protein C and S and as a cell signaling factor. Vitamin K1 is essential for blood coagulation, bone and vascular metabolism. Phylloquinone from green leafy vegetables and vegetable oil is the most important dietary source of vitamin K for humans.

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1 of 1

This Item
95271V-0305.01890
Vitamin K1 viscous liquid

Sigma-Aldrich

V3501

Vitamin K1

Vitamin K1 BioXtra, ≥99.0% (sum of isomers, HPLC), mixture of isomers

Sigma-Aldrich

95271

Vitamin K1

Vitamin K1 solution 10 μg/mL in ethanol, certified reference material, Cerilliant®

Supelco

V-030

Vitamin K1 solution

Vitamin K1 (phytomenadione) EMPROVE® ESSENTIAL Ph Eur,BP,USP,FCC

SAFC

5.01890

Vitamin K1 (phytomenadione)

biological source

synthetic (organic
inorganic)

biological source

synthetic

biological source

-

biological source

-

form

viscous liquid

form

viscous liquid

form

liquid

form

liquid

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

−70°C

storage temp.

15-25°C

mp

−20 °C (lit.)

mp

−20 °C (lit.)

mp

-143.99 °C

mp

-20 °C

color

, Yellow to Very Dark Yellow to Very Dark Orange

color

light green-yellow to dark green-yellow, light yellow to dark yellow

color

-

color

-

Quality Level

100

Quality Level

200

Quality Level

300

Quality Level

500

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Storage Class

10 - Combustible liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
BCCN2963
BCCM3613
BCCL7693
BCCK3926
MKCG2073

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Bacteroides disiens sp. nov. and Bacteroides bivius sp. nov. from human clinical infections
Holdeman L V and Johnson J L
International Journal of Systematic and Evolutionary Microbiology (1977)
Phylloquinone (vitamin K1): occurrence, biosynthesis and functions
Basset J G, et al.
Mini-Reviews in Medicinal Chemistry (2017)
Ellen M Apalset et al.
Bone, 49(5), 990-995 (2011-08-16)
Evidence of the effect of vitamin K on bone health is conflicting. The aim was to investigate the association between intake of vitamins K1 and K2 and subsequent risk of hip fracture in a general population sample, as well as
View All Related Papers

Global Trade Item Number

SKUGTIN
V3501-10G04061837480874
V3501-1G04061837480881
V3501-5G04061837480898

Questions

1–3 of 3 Questions  

  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf

      Helpful?

  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

      Helpful?

  3. How much of Vitamin K1 per litre of anaerobic gut-mimicking media is recommended?

    1 answer

    1. This is not an application that is QC tested, but the literature indicates that a good starting point might be 0.5 ug/mL. Please see: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6658209/

      Another option would be to use a Vitamin K1 ready-made solution, such as: https://www.sigmaaldrich.com/product/sigma/sbr00053

      This product is at a concentration of 5 mg/mL, but recommends dilution down to 1 ug/mL prior to use, and states that the optimal concentration may vary by strain so, further experimentation may be necessary to determine optimal conditions.

      Helpful?

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