Key Documents

View All Documentation

Valinomycin

Name: Valinomycin
Brand: SIGMA
Price: 128 USD
Availability: InStock

Ready Made Solution, ~1 mg/mL in DMSO

Synonym(s):

Cyclo(L-Val-D-HyIva-D-Val-L-Lac-)₃: HyIva = α-Hydroxyisovaleric acid, Lac = Lactic acid

Select a Size

Change View

Size/SKU	Availability	Price
5 mL	Check Cart for Availability	$128.00

About This Item

Empirical Formula (Hill Notation):

C₅₄H₉₀N₆O₁₈

CAS Number:

2001-95-8

Molecular Weight:

1111.32

UNSPSC Code:

51102829

NACRES:

NA.76

PubChem Substance ID:

24900743

MDL number:

MFCD00005114

Beilstein/REAXYS Number:

78657

$128.00

Check Cart for Availability

Request a Custom Order

Technical Service

Need help? Our team of experienced scientists is here for you.

Let Us Assist

Properties

biological source

Streptomyces sp.

Quality Segment

200

assay

≥90% (HPLC)

form

liquid, ready-to-use solution

storage condition

(Keep container tightly closed in a dry and well-ventilated place. Hydroscopic.)

concentration

~1 mg/mL in DMSO

color

colorless

antibiotic activity spectrum

Gram-positive bacteria, parasites, viruses

mode of action

cell membrane | interferes

shipped in

wet ice

storage temp.

2-8°C

SMILES string

CC(C)[C@@H]1NC(=O)[C@H](C)OC(=O)[C@@H](NC(=O)[C@H](OC(=O)[C@@H](NC(=O)[C@H](C)OC(=O)[C@H](NC(=O)[C@H](OC(=O)[C@@H](NC(=O)[C@H](C)OC(=O)[C@H](NC(=O)[C@H](OC1=O)C(C)C)C(C)C)C(C)C)C(C)C)C(C)C)C(C)C)C(C)C)C(C)C

InChI

1S/C54H90N6O18/c1-22(2)34-49(67)73-31(19)43(61)55-38(26(9)10)53(71)77-41(29(15)16)47(65)59-36(24(5)6)51(69)75-33(21)45(63)57-39(27(11)12)54(72)78-42(30(17)18)48(66)60-35(23(3)4)50(68)74-32(20)44(62)56-37(25(7)8)52(70)76-40(28(13)14)46(64)58-34/h22-42H,1-21H3,(H,55,61)(H,56,62)(H,57,63)(H,58,64)(H,59,65)(H,60,66)/t31-,32-,33-,34-,35+,36+,37-,38-,39-,40+,41+,42+/m0/s1

InChI key

FCFNRCROJUBPLU-RPUZOQEISA-N

Description

General description

Chemical structure: peptide

Application

Valinomycin is a cyclic dodecadepsipeptides with potassium ionophoric properties. It is used to study ion transport in biological systems. It is used to study its inhibitory effect on intact cells and the growth of bacteria and yeast. It is used to induce apoptosis.

Biochem/physiol Actions

Valinomycin is a K+-selective ionophoric cyclodepsipeptide. It is a potassium ionophore which uncouples oxidative phosphorylation, induces apoptosis in murine thymocytes, inhibits NGF-induced neuronal differentiation and antagonizes ET-induced vasoconstriction. It is reported to be insecticidal, nematicidal and antiviral.

K⁺-selective ionophore which uncouples oxidative phosphorylation.

K⁺-selective ionophoric cyclodepsipeptide; potassium ionophore which uncouples oxidative phosphorylation, induces apoptosis in murine thymocytes, inhibits NGF-induced neuronal differentiation and antagonizes ET-induced vasoconstriction.

Other Notes

Keep container tightly closed in a dry and well-ventilated place. Hygroscopic.

Compare Similar Items

View Full Comparison

Show Differences

1 of 1

This Item	94675	V0627	60403
Sigma-Aldrich V3639 Valinomycin	Sigma-Aldrich 94675 Valinomycin	Sigma-Aldrich V0627 Valinomycin	Supelco 60403 Potassium ionophore I
description Ready Made Solution, ~1 mg/mL in DMSO	description ≥99.0% (TLC)	description ≥98% (TLC), ≥90% (HPLC)	description Selectophore^™, function tested
mode of action cell membrane \| interferes	mode of action cell membrane \| interferes	mode of action cell membrane \| interferes	mode of action -
antibiotic activity spectrum Gram-positive bacteria, parasites, viruses	antibiotic activity spectrum mycobacteria	antibiotic activity spectrum viruses, parasites, Gram-positive bacteria	antibiotic activity spectrum -
Quality Level 200	Quality Level 200	Quality Level 300	Quality Level 200
form liquid, ready-to-use solution	form powder	form powder	form powder or crystals
assay ≥90% (HPLC)	assay ≥99.0% (TLC)	assay ≥90% (HPLC), ≥98% (TLC)	assay ≥90.0% (HPLC)
biological source Streptomyces sp.	biological source -	biological source -	biological source -

Still not finding the right product?

Explore all of our products under Valinomycin

Storage Class

10 - Combustible liquids

WGK

WGK 1

Flash Point (°F)

188.6 °F - closed cup

Flash Point (°C)

87 °C - closed cup

PPE (personal protective equipment)

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

It looks like we've run into a problem, but you can still download Certificates of Analysis from our Documents section.

If you need assistance, please contact Customer Support

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.