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V3639

Valinomycin

Ready Made Solution, ~1 mg/mL in DMSO

Synonym(s):

Cyclo(L-Val-D-HyIva-D-Val-L-Lac-)3: HyIva = α-Hydroxyisovaleric acid, Lac = Lactic acid

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Size/SKUAvailabilityPrice
5 mL
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$123.00

About This Item

Empirical Formula (Hill Notation):
C54H90N6O18
CAS Number:
Molecular Weight:
1111.32
UNSPSC Code:
51102829
NACRES:
NA.76
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
78657

$123.00


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biological source

Streptomyces sp.

Quality Segment

assay

≥90% (HPLC)

form

liquid, ready-to-use solution

storage condition

(Keep container tightly closed in a dry and well-ventilated place. Hydroscopic.)

concentration

~1 mg/mL in DMSO

color

colorless

antibiotic activity spectrum

Gram-positive bacteria, parasites, viruses

mode of action

cell membrane | interferes

shipped in

wet ice

storage temp.

2-8°C

SMILES string

CC(C)[C@@H]1NC(=O)[C@H](C)OC(=O)[C@@H](NC(=O)[C@H](OC(=O)[C@@H](NC(=O)[C@H](C)OC(=O)[C@H](NC(=O)[C@H](OC(=O)[C@@H](NC(=O)[C@H](C)OC(=O)[C@H](NC(=O)[C@H](OC1=O)C(C)C)C(C)C)C(C)C)C(C)C)C(C)C)C(C)C)C(C)C)C(C)C

InChI

1S/C54H90N6O18/c1-22(2)34-49(67)73-31(19)43(61)55-38(26(9)10)53(71)77-41(29(15)16)47(65)59-36(24(5)6)51(69)75-33(21)45(63)57-39(27(11)12)54(72)78-42(30(17)18)48(66)60-35(23(3)4)50(68)74-32(20)44(62)56-37(25(7)8)52(70)76-40(28(13)14)46(64)58-34/h22-42H,1-21H3,(H,55,61)(H,56,62)(H,57,63)(H,58,64)(H,59,65)(H,60,66)/t31-,32-,33-,34-,35+,36+,37-,38-,39-,40+,41+,42+/m0/s1

InChI key

FCFNRCROJUBPLU-RPUZOQEISA-N

General description

Chemical structure: peptide

Application

Valinomycin is a cyclic dodecadepsipeptides with potassium ionophoric properties. It is used to study ion transport in biological systems. It is used to study its inhibitory effect on intact cells and the growth of bacteria and yeast. It is used to induce apoptosis[1].

Biochem/physiol Actions

K+-selective ionophore which uncouples oxidative phosphorylation.
K+-selective ionophoric cyclodepsipeptide; potassium ionophore which uncouples oxidative phosphorylation, induces apoptosis in murine thymocytes, inhibits NGF-induced neuronal differentiation and antagonizes ET-induced vasoconstriction.
Valinomycin is a K+-selective ionophoric cyclodepsipeptide. It is a potassium ionophore which uncouples oxidative phosphorylation, induces apoptosis in murine thymocytes, inhibits NGF-induced neuronal differentiation and antagonizes ET-induced vasoconstriction. It is reported to be insecticidal, nematicidal and antiviral[1].

Other Notes

Keep container tightly closed in a dry and well-ventilated place. Hygroscopic.

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This Item
V06276040394675
description

Ready Made Solution, ~1 mg/mL in DMSO

description

≥98% (TLC), ≥90% (HPLC)

description

Selectophore, function tested

description

≥99.0% (TLC)

antibiotic activity spectrum

Gram-positive bacteria, viruses, parasites

antibiotic activity spectrum

Gram-positive bacteria, parasites, viruses

antibiotic activity spectrum

-

antibiotic activity spectrum

mycobacteria

Quality Level

200

Quality Level

300

Quality Level

200

Quality Level

200

form

liquid, ready-to-use solution

form

powder

form

powder or crystals

form

powder

assay

≥90% (HPLC)

assay

≥90% (HPLC), ≥98% (TLC)

assay

≥90.0% (HPLC)

assay

≥99.0% (TLC)

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

biological source

Streptomyces sp.

biological source

-

biological source

-

biological source

-


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Storage Class

10 - Combustible liquids

wgk

WGK 1

flash_point_f

188.6 °F - closed cup

flash_point_c

87 °C - closed cup

ppe

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter



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