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V6758

VEGF Receptor-2 (Flk-1, KDR)/Fc Chimera human

>90% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder

Synonym(s):

Vascular Endothelial Growth Factor Receptor‑2

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50 μg
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$817.00

About This Item

UNSPSC Code:
51111800
NACRES:
NA.32
MDL number:
MFCD03101926
Form:
lyophilized powder
Assay:
>90% (SDS-PAGE)
Biological source:
human
Recombinant:
expressed in NSO cells
Mol wt:
predicted mol wt ~110 kDa

$817.00

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biological source

human

Quality Segment

recombinant

expressed in NSO cells

assay

>90% (SDS-PAGE)

form

lyophilized powder

potency

10-40 ng/mL ED50

mol wt

predicted mol wt ~110 kDa

packaging

pkg of 50 μg

storage condition

avoid repeated freeze/thaw cycles

impurities

endotoxin, tested

UniProt accession no.

storage temp.

−20°C

Gene Information

human ... KDR(3791)

Application

VEGF Receptor-2 (Flk-1, KDR)/Fc Chimera human is a homodimeric protein contains extracellular domain of human VEGF R2 (KDR) fused to the 6x histidine tagged Fc portion of human IgG1 by the peptide (EGF). The product was used to stuyd vasculogenesis and angiogenesis and as marker for pluripotent hematopoietic stem cells.

Biochem/physiol Actions

VEGF Receptor-2 (VEGF R2) also known as Flk-1 or KDR belongs to class III subfamily of RTKs is a potent VEGF antagonist and is mainly expressed in endothelial cells. VEGF R2 can stimulate PLC-gamma pathway which in turn activate MAP kinase and subsequent strong signalling as well as can partly induces mitotic signals in NIH3T3 fibroblasts. KDR also facilitates the release of nitric oxide in endothelial cells and assist in the regulation of the vasculature.
VEGF receptors, class III receptor tyrosine kinases, have seven Ig like extracellular motifs and a tyrosine kinase intracellular domain split by a kinase insert sequence. VEGFR 1 and 2 are both expressed in an endothelial cell-specific manner.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing 2.5 mg bovine serum albumin.

Analysis Note

The biological activity is measured by its ability to inhibit the VEGF-dependent proliferation of human umbilical vein endothelial cells.

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This Item
V9134V1385SAB5700811
VEGF Receptor-2 (Flk-1, KDR)/Fc Chimera human >90% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder

Sigma-Aldrich

V6758

VEGF Receptor-2 (Flk-1, KDR)/Fc Chimera human

Monoclonal Anti-Vascular Endothelial Growth Factor Receptor-2 antibody produced in mouse clone KDR-1, ascites fluid

Sigma-Aldrich

V9134

Monoclonal Anti-Vascular Endothelial Growth Factor Receptor-2 antibody produced in mouse

VEGF Receptor-1 (Flt-1)/Fc Chimera human >90% (SDS-PAGE), recombinant, expressed in baculovirus infected Sf21 cells, lyophilized powder

Sigma-Aldrich

V1385

VEGF Receptor-1 (Flt-1)/Fc Chimera human

Anti-VEGF Receptor 2 antibody produced in rabbit

Sigma-Aldrich

SAB5700811

Anti-VEGF Receptor 2 antibody produced in rabbit

description

>90% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder

description

clone KDR-1, ascites fluid

description

>90% (SDS-PAGE), recombinant, expressed in baculovirus infected Sf21 cells, lyophilized powder

description

-

assay

>90% (SDS-PAGE)

assay

-

assay

>90% (SDS-PAGE)

assay

-

biological source

human

biological source

mouse

biological source

human

biological source

rabbit

recombinant

expressed in NSO cells

recombinant

-

recombinant

expressed in baculovirus infected Sf21 cells

recombinant

-

mol wt

predicted mol wt ~110 kDa

mol wt

-

mol wt

predicted mol wt ~100 kDa

mol wt

75, 79, 151

form

lyophilized powder

form

-

form

lyophilized powder

form

buffered aqueous solution

impurities

endotoxin, tested

impurities

-

impurities

endotoxin, tested

impurities

-

Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

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