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Monoclonal Anti-Vascular Endothelial Growth Factor Receptor-2 antibody produced in mouse

Name: Monoclonal Anti-Vascular Endothelial Growth Factor Receptor-2 antibody produced in mouse
Brand: SIGMA
Price: 890 USD
Availability: InStock

clone KDR-1, ascites fluid

Synonym(s):

Anti-KDR, Anti-VEGF R-2

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0.2 mL	Check Cart for Availability	$890.00

About This Item

UNSPSC Code:

51111800

NACRES:

NA.41

MDL number:

MFCD01634355

Conjugate:

unconjugated

Clone:

KDR-1, monoclonal

Application:

ELISA (i), IHC (f)

Citations:

$890.00

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Properties

biological source

mouse

Quality Segment

200

conjugate

unconjugated

antibody form

ascites fluid

antibody product type

primary antibodies

clone

KDR-1, monoclonal

contains

15 mM sodium azide

species reactivity

human

technique(s)

immunohistochemistry (frozen sections): 1:800 using human placenta, indirect ELISA: suitable

isotype

IgG1

UniProt accession no.

P35968

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... KDR(3791)

Description

General description

Monoclonal Anti-Vascular Endothelial Growth Factor Receptor-2 (mouse IgG1 isotype) is derived from the KDR-1 hybridoma produced by the fusion of mouse myeloma cells and splenocytes from an immunized mouse. Vascular endothelial growth factor (VEGF), is a homodimeric heparin-binding glycoprotein. It is a member of a family of endothelial cell mitogenic and angiogenic factors. The VEGFR2 gene has been mapped to human chromosome 4q11-q12, which is the same locus for PDGF receptor and c-kit.

The antibody reacts specifically with VEGF receptor 2 (KDR) and does not recognize VEGF receptor-1 (Flt1 receptor), VEGF receptor 3 (sFlt4), and PDGF-Rβ.

Immunogen

recombinant human extracellular domain of VEGFR-2 (KDR).

Application

Monoclonal Anti-Vascular Endothelial Growth Factor Receptor-2 antibody produced in mouse has been used in:

immunohistochemistry
histology
immunostaining
enzyme linked immunosorbent assay (ELISA)

Monoclonal Anti-Vascular Endothelial Growth Factor Receptor-2 antibody produced in mouse was used for FACS analysis of HUVECs.

Biochem/physiol Actions

Vascular endothelial growth factor (VEGF) specifically stimulates the proliferation of endothelial cells isolated from both small and large vessels. These include endothelial cells from adrenal cortex, cerebral cortex, fetal and adult aorta and human umbilical vein.

Vascular endothelial growth factors receptors (VEGF Rs) are receptor tyrosine kinases that bind to VEGF. VEGF plays an important role in embryonic vasculogenesis, angiogenesis and homeostasis. The binding of VEGF to VEGF R2 results in activation of MAPK, PI3K, PKC, FAK and Src kinase pathways. The biological roles of VEGF R2 include in epithelial cell growth, proliferation, survival, migration, vascular permeability and angiogenesis.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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This Item	B0555	SAB5700811	SAB4504567
Sigma-Aldrich V9134 Monoclonal Anti-Vascular Endothelial Growth Factor Receptor-2 antibody produced in mouse	Sigma-Aldrich B0555 Anti-Vascular Endothelial Growth Factor Receptor-2 (KDR)−Biotin Conjugate antibody, Mouse monoclonal	Sigma-Aldrich SAB5700811 Anti-VEGF Receptor 2 antibody produced in rabbit	Sigma-Aldrich SAB4504567 Anti-phospho-VEGFR2 (pTyr¹¹⁷⁵) antibody produced in rabbit
description clone KDR-1, ascites fluid	description clone 260.4, KDR-2, purified from hybridoma cell culture	description -	description affinity isolated antibody
conjugate unconjugated	conjugate biotin conjugate	conjugate unconjugated	conjugate unconjugated
biological source mouse	biological source mouse	biological source rabbit	biological source rabbit
clone KDR-1, monoclonal	clone 260.4, KDR-2, monoclonal	clone polyclonal	clone polyclonal
species reactivity human	species reactivity human	species reactivity human, rat, mouse	species reactivity human, rat, mouse
antibody form ascites fluid	antibody form purified from hybridoma cell culture	antibody form affinity isolated antibody	antibody form affinity isolated antibody
Gene Information human ... KDR(3791)	Gene Information human ... KDR(3791)	Gene Information human ... KDR(3791)	Gene Information human ... KDR(3791)

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Storage Class

10 - Combustible liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

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