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W1020

W146 hydrate

≥98% (HPLC)

Synonym(s):

ML056, R-3-amino-4-(3-hexylphenylamino)-4-oxobutylphosphonic acid hydrate, [(3R)-3-amino-4-[(3-hexylphenyl)amino]-4-oxobutyl]-phosphonic acid

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Size/SKUAvailabilityPrice
1 mg

Available to ship TODAYfromMILWAUKEE

$258.00
$219.30
5 mg

Available to ship TODAYfromMILWAUKEE

$1,020.00

About This Item

Empirical Formula (Hill Notation):
C16H27N2O4P · xH2O
CAS Number:
Molecular Weight:
342.37 (anhydrous basis)
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352211
MDL number:
Assay:
≥98% (HPLC)
Form:
powder

$219.30

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Quality Segment

assay

≥98% (HPLC)

form

powder

color

off-white

solubility

methanol: soluble (with 0.1% TFA)

originator

Novartis

storage temp.

2-8°C

SMILES string

O.CCCCCCc1cccc(NC(=O)[C@H](N)CCP(O)(O)=O)c1

InChI

1S/C16H27N2O4P.H2O/c1-2-3-4-5-7-13-8-6-9-14(12-13)18-16(19)15(17)10-11-23(20,21)22;/h6,8-9,12,15H,2-5,7,10-11,17H2,1H3,(H,18,19)(H2,20,21,22);1H2/t15-;/m1./s1

InChI key

DQKSZHVSROOTFY-XFULWGLBSA-N

General description

W146 hydrate functions as an orthosteric antagonist. It is associated with blood lymphopenia and lung edema in mice.

Application

W146 hydrate has been used to assess vascular permeability in mice.

Biochem/physiol Actions

Potent S1P(1) competitive antagonist; Ki = 10-77 nM.

Features and Benefits

This compound is featured on the Lysophospholipid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

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This Item
S3445SML0063SML0178
description

≥98% (HPLC)

description

≥98% (HPLC)

description

≥95% (HPLC)

description

≥98% (HPLC)

form

powder

form

powder

form

powder

form

powder

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥95% (HPLC)

assay

≥98% (HPLC)

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

2-8°C

solubility

methanol: soluble (with 0.1% TFA)

solubility

DMSO: ≥20 mg/mL, H2O: ≥20 mg/mL

solubility

DMSO: ≥14 mg/mL

solubility

H2O: ≥5 mg/mL

originator

Novartis

originator

-

originator

-

originator

AstraZeneca


Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable



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