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Anti-XPC (C-terminal) antibody produced in rabbit

Name: Anti-XPC (C-terminal) antibody produced in rabbit
Brand: SIGMA
Price: 587.35 USD
Availability: InStock

~1 mg/mL, affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti-Xeroderma pigmentosum, complementary group C, Anti-XP3, Anti-XPCC

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Size/SKU	Availability	Price
200 μL	Available to ship TODAYfromMILWAUKEE	$691.00 $587.35

About This Item

UNSPSC Code:

12352203

NACRES:

NA.41

MDL number:

MFCD09265382

Conjugate:

unconjugated

Clone:

polyclonal

Application:

IF, WB

Citations:

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Properties

biological source

rabbit

Quality Segment

200

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 120 kDa

species reactivity

human

concentration

~1 mg/mL

technique(s)

indirect immunofluorescence: 5-10 μg/mL using MCF7 cells fixed with paraformaldehyde-Triton, western blot: 0.5-1 μg/mL using MCF-7 cell lysates

UniProt accession no.

Q01831

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... XPC(7508)

Description

General description

DNA damage recognition and repair factor, XPC complex subunit xeroderma pigmentosum group C (XPC) is a DNA damage recognition factor. The protein consists of 940 amino acids. The gene encoding XPC is localized on human chromosome 3p25.1 and consists of 18 exons.

XPC exists in vivo as a heterotrimeric complex with one of the two mammalian homologs of S. cerevisiae Rad23 (HR23A or HR23B) and centrin 2.

Immunogen

synthetic peptide corresponding to amino acids 922-940 of human XPC, conjugated to KLH via an N-terminal added cysteine residue.

Application

Anti-XPC (C-terminal) antibody produced in rabbit has been used in indirect immunofluorescence and western blotting

Biochem/physiol Actions

DNA damage recognition and repair factor, XPC complex subunit xeroderma pigmentosum group C (XPC) has a role in global genome nucleotide excision repair pathway. As part of the XPC complex, this protein binds to DNA sites having many lesions. Single nucleotide polymorphisms in the XPC gene have been linked to various cancers.

Defective XPC gene causes photosensitivity syndrome called xeroderma pigmentosum (XP), which is characterized by a very high incidence of light-induced skin cancer.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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This Item	HPA035707	HPA069673	SAB2702172
Sigma-Aldrich X1129 Anti-XPC (C-terminal) antibody produced in rabbit	Sigma-Aldrich HPA035707 Anti-XPC antibody produced in rabbit	Sigma-Aldrich HPA069673 Anti-XPC antibody produced in rabbit	Sigma-Aldrich SAB2702172 Monoclonal Anti-XPC antibody produced in mouse
description ~1 mg/mL, affinity isolated antibody, buffered aqueous solution	description Prestige Antibodies^® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution	description Prestige Antibodies^® Powered by Atlas Antibodies, affinity isolated antibody	description -
Quality Level 200	Quality Level 100	Quality Level 100	Quality Level 100
biological source rabbit	biological source rabbit	biological source rabbit	biological source mouse
conjugate unconjugated	conjugate unconjugated	conjugate unconjugated	conjugate unconjugated
antibody form affinity isolated antibody	antibody form affinity isolated antibody	antibody form affinity isolated antibody	antibody form purified immunoglobulin
UniProt accession no. Q01831	UniProt accession no. Q01831	UniProt accession no. Q01831	UniProt accession no. Q01831
species reactivity human	species reactivity human	species reactivity human	species reactivity human, mouse

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Storage Class

10 - Combustible liquids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

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