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X3629

X80

≥98% (HPLC)

Synonym(s):

5-(5-{[1-(3-carboxyphenyl)-3-methyl-5-oxo-1,5-dihydro-4H-pyrazol-4-ylidene]methyl}-2-furyl)-2-chlorobenzoic acid

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Size/SKUAvailabilityPrice
5 mg

Available to ship TODAYfromMILWAUKEE

$156.40

About This Item

Empirical Formula (Hill Notation):
C23H15ClN2O6
CAS Number:
Molecular Weight:
450.83
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Assay:
≥98% (HPLC)
Form:
powder

$156.40

List Price$184.00Save 15%

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Quality Segment

assay

≥98% (HPLC)

form

powder

color

orange

solubility

DMSO: >40 mg/mL

storage temp.

2-8°C

SMILES string

CC1=NN(c2cccc(c2)C(O)=O)C(=O)\C1=C/c3ccc(o3)-c4ccc(Cl)c(c4)C(O)=O

InChI

1S/C23H15ClN2O6/c1-12-17(21(27)26(25-12)15-4-2-3-14(9-15)22(28)29)11-16-6-8-20(32-16)13-5-7-19(24)18(10-13)23(30)31/h2-11H,1H3,(H,28,29)(H,30,31)/b17-11-

InChI key

XZRBYOCWWJMJRZ-BOPFTXTBSA-N

Application

X80 has been used as an inhibitor of nucleotide excision repair (NER) pathway to study its effects on 8-hydroxy-2′-deoxyguanosine (8-OHdG) excision in the zygote post-fertilization.

Biochem/physiol Actions

X80 is a XPA protein inhibitor.
X80 is an inhibitor of xeroderma pigmentosum group A protein (XPA protein) required for the removal of all types of DNA lesions repaired by nucleotide excision repair Including both transcription coupled and global genomic nucleotide excision repair.

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This Item
SML0922262015X1129
description

≥98% (HPLC)

description

≥98% (HPLC)

description

The DNA Base Excision Repair Pathway Inhibitor, also referenced under CAS 6960-45-8, controls the biological activity of APE1 (human apurinic/apyrimidinic endonuclease.

description

~1 mg/mL, affinity isolated antibody, buffered aqueous solution

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

-

form

powder

form

powder

form

solid

form

buffered aqueous solution

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

200

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

−20°C

solubility

DMSO: >40 mg/mL

solubility

H2O: 10 mg/mL, clear

solubility

DMSO: 5 mg/mL

solubility

-

color

orange

color

yellow to orange

color

tan

color

-


Pictograms

Exclamation mark

Signal Word

Warning

Hazard Codes

Precautionary Statements

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Chronic 4

Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable



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