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Y1271

YM-202074 sesquifumarate salt hydrate

≥98% (HPLC)

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Synonym(s):

N-cyclohexyl-6-{[(2-methoxyethyl)(methyl)amino]methyl}-N-methylthiazolo[3,2-a]benzimidazole-2-carboxamide, YM 202074, YM202074

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Size/SKUAvailabilityPrice
25 mg

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$495.00

About This Item

Empirical Formula (Hill Notation):
C22H30N4O2S · 1.5C4H4O4 · xH2O
CAS Number:
Molecular Weight:
588.67 (anhydrous basis)
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Assay:
≥98% (HPLC)
Form:
powder

$495.00

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Quality Segment

assay

≥98% (HPLC)

form

powder

color

white to off-white

solubility

DMSO: >20 mg/mL, H2O: >5 mg/mL

storage temp.

room temp

SMILES string

O.OC(=O)\C=C\C(O)=O.OC(=O)\C=C\C(O)=O.COCCN(C)Cc1ccc2nc3sc(cn3c2c1)C(=O)N(C)C4CCCCC4.COCCN(C)Cc5ccc6nc7sc(cn7c6c5)C(=O)N(C)C8CCCCC8.COCCN(C)Cc9ccc%10nc%11sc(cn%11c%10c9)C(=O)N(C)C%12CCCCC%12

InChI

1S/3C22H30N4O2S.2C4H4O4.H2O/c3*1-24(11-12-28-3)14-16-9-10-18-19(13-16)26-15-20(29-22(26)23-18)21(27)25(2)17-7-5-4-6-8-17;2*5-3(6)1-2-4(7)8;/h3*9-10,13,15,17H,4-8,11-12,14H2,1-3H3;2*1-2H,(H,5,6)(H,7,8);1H2/b;;;2*2-1+;

InChI key

MCGFIZFYSARKON-RAMYONIISA-N

Biochem/physiol Actions

YM-202074 is a potent and selective allosteric metabotropic glutamate receptor type 1 (mGluR1) antagonist.
YM-202074 is a potent and selective allosteric metabotropic glutamate receptor type 1 (mGluR1) antagonist. It bound an allosteric site of rat mGluR1 with a Ki value of 4.8 nM. It also inhibited the mGluR1-mediated inositol phosphates production in rat cerebellar granule cells with an IC50 value of 8.6 nM, while showing selectivity over mGluR(2-7).

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This Item
SML2650PZ0016
description

≥98% (HPLC)

description

≥98% (HPLC)

description

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

form

powder

form

powder

form

powder

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

room temp

storage temp.

room temp

storage temp.

room temp

solubility

H2O: >5 mg/mL, DMSO: >20 mg/mL

solubility

DMSO: 2 mg/mL, clear (warmed)

solubility

DMSO: >20 mg/mL

color

white to off-white

color

white to beige

color

white to off-white


Pictograms

Skull and crossbones

Signal Word

Danger

Hazard Codes

Hazard Classifications

Acute Tox. 3 Oral - Eye Irrit. 2

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable



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