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Z2126

ZAP-70 Tyrosine Kinase human

≥90% (SDS-PAGE), recombinant, expressed in baculovirus infected insect cells (Histidine tagged), buffered aqueous glycerol solution, ≥150 U/mg

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20 μg
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$1,020.00

About This Item

UNSPSC Code:
12352200
NACRES:
NA.32
MDL number:
MFCD03459122
Specific activity:
≥150 U/mg
Assay:
≥90% (SDS-PAGE)
Recombinant:
expressed in baculovirus infected insect cells (Histidine tagged)

$1,020.00

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recombinant

expressed in baculovirus infected insect cells (Histidine tagged)

Quality Segment

200

assay

≥90% (SDS-PAGE)

form

buffered aqueous glycerol solution

specific activity

≥150 U/mg

mol wt

70 kDa

UniProt accession no.

P43403

shipped in

dry ice

storage temp.

−70°C

Gene Information

human ... ZAP70(7535)

Application

Human ZAP-70 Tyrosine Kinase was used for mapping the phosphorylation sites on LAT (linker for activation of T cells) for investigating the mechanism of activation of signalling proteins in T cells.

Biochem/physiol Actions

ZAP-70 Tyrosine Kinase is a protein belongs to Syk family and is essential for T cell activation. It facilitates the upregulation of Fas ligand in activation-induced T cell apoptosis. Additionally, it also plays a pivotal role in LFA-1-dependent T Cell Migration.
ZAP-70 is protein tyrosine kinase of the Syk family that is localized exclusively to the cytosol of T cells and natural killer cells. It is required for T cell activation. It is activated by Lck-mediated phosphorylation of its tyrosine residues.

Physical form

Solution in 25 mM HEPES, pH 7.5, containing 150 mM NaCl, 0.5 mM DTT, and 50% glycerol.

Other Notes

One unit will phosphorylate 1 nmol polyglutamic acid:tyrosine per min at 37 °C at pH 7.0.

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ZAP-70 Tyrosine Kinase human ≥90% (SDS-PAGE), recombinant, expressed in baculovirus infected insect cells (Histidine tagged), buffered aqueous glycerol solution, ≥150 U/mg

Sigma-Aldrich

Z2126

ZAP-70 Tyrosine Kinase human

Anti-phospho-ZAP-70 (pTyr315) antibody produced in rabbit affinity isolated antibody

Sigma-Aldrich

SAB4504012

Anti-phospho-ZAP-70 (pTyr315) antibody produced in rabbit

Anti-ZAP-70 antibody produced in rabbit affinity isolated antibody

Sigma-Aldrich

SAB4503107

Anti-ZAP-70 antibody produced in rabbit

Monoclonal Anti-ZAP-70 antibody produced in mouse ~1.5 mg/mL, clone 1E7.2, purified immunoglobulin, buffered aqueous solution

Sigma-Aldrich

Z0627

Monoclonal Anti-ZAP-70 antibody produced in mouse

description

≥90% (SDS-PAGE), recombinant, expressed in baculovirus infected insect cells (Histidine tagged), buffered aqueous glycerol solution, ≥150 U/mg

description

affinity isolated antibody

description

affinity isolated antibody

description

~1.5 mg/mL, clone 1E7.2, purified immunoglobulin, buffered aqueous solution

assay

≥90% (SDS-PAGE)

assay

-

assay

-

assay

-

specific activity

≥150 U/mg

specific activity

-

specific activity

-

specific activity

-

Gene Information

human ... ZAP70(7535)

Gene Information

human ... ZAP70(7535)

Gene Information

human ... ZAP70(7535)

Gene Information

human ... ZAP70(7535)
mouse ... Zap70(22637)

recombinant

expressed in baculovirus infected insect cells (Histidine tagged)

recombinant

-

recombinant

-

recombinant

-

form

buffered aqueous glycerol solution

form

buffered aqueous solution

form

buffered aqueous solution

form

buffered aqueous solution

storage temp.

−70°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

Storage Class

10 - Combustible liquids

wgk

WGK 1

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