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Allopurinol

Name: Allopurinol
Brand: USP
Price: 455 USD
Availability: InStock

United States Pharmacopeia (USP) Reference Standard

Synonym(s):

1H-Pyrazolo(3,4-d)pyrimidin-4-ol, 4-Hydroxypyrazolo(3,4-d)pyrimidine, 4-Hydroxypyrazolo[3,4-d]pyrimidine, HPP

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Pack Size	SKU	Availability	Price
250 mg		Available to ship TODAYfromMILWAUKEE	$455.00

About This Item

Empirical Formula (Hill Notation):

C₅H₄N₄O

CAS Number:

315-30-0

Molecular Weight:

136.11

NACRES:

NA.24

PubChem Substance ID:

329748958

UNSPSC Code:

41116107

MDL number:

MFCD00599413

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Properties

grade

pharmaceutical primary standard

API family

allopurinol

manufacturer/tradename

USP

mp

>300 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

15-25°C

SMILES string

O=C1NC=Nc2[nH]ncc12

InChI

1S/C5H4N4O/c10-5-3-1-8-9-4(3)6-2-7-5/h1-2H,(H2,6,7,8,9,10)

InChI key

OFCNXPDARWKPPY-UHFFFAOYSA-N

Gene Information

human ... XDH(7498)

Description

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Allopurinol USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:

Allopurinol Compounded Oral Suspension
Allopurinol Tablets

Biochem/physiol Actions

Inhibitor of xanthine oxidase and de novo pyrimidine biosynthesis. A classical agent in treatment of hyperuricemia and gout.

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.

Other Notes

Sales restrictions may apply.

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This Item	A0350000	BP870	PHR1377
USP 1013002 Allopurinol	A0350000 Allopurinol	BP870 Allopurinol	Supelco PHR1377 Allopurinol
grade pharmaceutical primary standard	grade pharmaceutical primary standard	grade pharmaceutical primary standard	grade certified reference material, pharmaceutical secondary standard
manufacturer/tradename USP	manufacturer/tradename EDQM	manufacturer/tradename BP	manufacturer/tradename -
application(s) pharmaceutical (small molecule)	application(s) pharmaceutical (small molecule)	application(s) pharmaceutical pharmaceutical small molecule	application(s) pharmaceutical (small molecule)
format neat	format neat	format neat	format neat
API family allopurinol	API family allopurinol	API family allopurinol	API family allopurinol
Gene Information human ... XDH(7498)	Gene Information human ... XDH(7498)	Gene Information human ... XDH(7498)	Gene Information human ... XDH(7498)

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pictograms

GHS06

signalword

Danger

hcodes

H301,H317

pcodes

P261 - P264 - P270 - P280 - P301 + P310 - P302 + P352

Hazard Classifications

Acute Tox. 3 Oral - Skin Sens. 1

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

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A vascular mechanism for high-sodium-induced insulin resistance in rats.

Dino Premilovac et al.

Diabetologia, 57(12), 2586-2595 (2014-09-13)

High sodium (HS) effects on hypertension are well established. Recent evidence implicates a relationship between HS intake and insulin resistance, even in the absence of hypertension. The aim of the current study was to determine whether loss of the vascular

NADPH oxidase-derived reactive oxygen species contribute to impaired cutaneous microvascular function in chronic kidney disease.

Jennifer J DuPont et al.

American journal of physiology. Renal physiology, 306(12), F1499-F1506 (2014-04-25)

Oxidative stress promotes vascular dysfunction in chronic kidney disease (CKD). We utilized the cutaneous circulation to test the hypothesis that reactive oxygen species derived from NADPH oxidase and xanthine oxidase impair nitric oxide (NO)-dependent cutaneous vasodilation in CKD. Twenty subjects

Genome-wide association study identifies ABCG2 (BCRP) as an allopurinol transporter and a determinant of drug response.

C C Wen et al.

Clinical pharmacology and therapeutics, 97(5), 518-525 (2015-02-14)

The first-line treatment of hyperuricemia, which causes gout, is allopurinol. The allopurinol response is highly variable, with many users failing to achieve target serum uric acid (SUA) levels. No genome-wide association study (GWAS) has examined the genetic factors affecting allopurinol

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Global Trade Item Number

SKU	GTIN
1013002-250MG	04061838667700

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