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Thioguanine

Name: Thioguanine
Brand: USP
Price: 408 USD
Availability: InStock

United States Pharmacopeia (USP) Reference Standard

Synonym(s):

6-Thioguanine, 2-Amino-6-mercaptopurine, 2-Amino-6-purinethiol

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Pack Size	SKU	Availability	Price
200 mg		Estimated to ship onMay 25, 2026fromMILWAUKEE	$408.00

About This Item

Empirical Formula (Hill Notation):

C₅H₅N₅S

CAS Number:

154-42-7

Molecular Weight:

167.19

UNSPSC Code:

41116107

NACRES:

NA.24

PubChem Substance ID:

329751279

MDL number:

MFCD00233553

Beilstein/REAXYS Number:

157765

$408.00

Estimated to ship onMay 25, 2026Details

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Properties

grade

pharmaceutical primary standard

API family

thioguanine, tioguanine

manufacturer/tradename

USP

mp

≥300 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

SMILES string

NC1=Nc2nc[nH]c2C(=S)N1

InChI

1S/C5H5N5S/c6-5-9-3-2(4(11)10-5)7-1-8-3/h1H,(H4,6,7,8,9,10,11)

InChI key

WYWHKKSPHMUBEB-UHFFFAOYSA-N

Gene Information

human ... IMPDH1(3614), IMPDH2(3615)

Description

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Thioguanine USP Reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monograph such as Thioguanine Tablets

Biochem/physiol Actions

Ribosylated and phosphorylated by the same pathway as natural purine bases; as the nucleotide, inhibits a variety of cellular processes involved in nucleic acid synthesis. Has a long history as an effective treatment of leukemia.

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.

Other Notes

Sales restrictions may apply.

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1 of 1

This Item	BP878	PHR3250	1392002
USP 1660000 Thioguanine	BP878 Tioguanine	Supelco PHR3250 Thioguanine	USP 1392002 Mercaptopurine
manufacturer/tradename USP	manufacturer/tradename BP	manufacturer/tradename -	manufacturer/tradename USP
grade pharmaceutical primary standard	grade pharmaceutical primary standard	grade certified reference material, pharmaceutical secondary standard	grade pharmaceutical primary standard
format neat	format neat	format -	format neat
application(s) pharmaceutical (small molecule)	application(s) pharmaceutical pharmaceutical small molecule	application(s) pharmaceutical	application(s) pharmaceutical (small molecule)
Gene Information human ... IMPDH1(3614), IMPDH2(3615)	Gene Information human ... IMPDH1(3614), IMPDH2(3615)	Gene Information -	Gene Information human ... PPAT(5471)
API family thioguanine, tioguanine	API family thioguanine, tioguanine	API family tioguanine, thioguanine	API family mercaptopurine

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pictograms

GHS06

signalword

Danger

hcodes

H301

pcodes

P301 + P330 + P331 + P310

Hazard Classifications

Acute Tox. 3 Oral

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Anti-metastatic activity of the tumor vascular targeting agent NGR-TNF.

Paola Di Matteo et al.

Clinical & experimental metastasis, 32(3), 289-300 (2015-02-05)

Tumor vessels are an attractive target for cancer therapy, including metastasis treatment. Angiogenesis inhibitors targeting the VEGF signalling pathway have proven to be efficacious in preclinical cancer models and in clinical trials. However, angiogenesis inhibition concomitantly elicits tumor adaptation and

Evasion of innate cytosolic DNA sensing by a gammaherpesvirus facilitates establishment of latent infection.

Chenglong Sun et al.

Journal of immunology (Baltimore, Md. : 1950), 194(4), 1819-1831 (2015-01-18)

Herpesviruses are DNA viruses harboring the capacity to establish lifelong latent-recurrent infections. There is limited knowledge about viruses targeting the innate DNA-sensing pathway, as well as how the innate system impacts on the latent reservoir of herpesvirus infections. In this

Thiopurine dose intensity and treatment outcome in childhood lymphoblastic leukaemia: the influence of thiopurine methyltransferase pharmacogenetics.

Lynne Lennard et al.

British journal of haematology, 169(2), 228-240 (2014-12-03)

The impact of thiopurine methyltransferase (TPMT) genotype on thiopurine dose intensity, myelosuppression and treatment outcome was investigated in the United Kingdom childhood acute lymphoblastic leukaemia (ALL) trial ALL97. TPMT heterozygotes had significantly more frequent cytopenias and therefore required dose adjustments

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Global Trade Item Number

SKU	GTIN
1660000-200MG	04061833833445

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