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Merck

56968

Sparfloxacin

≥98.0% (HPLC)

Synonym(e):

5-Amino-1-cyclohexyl-7-(cis-3,5-dimethylpiperazino)-6,8-difluor-1,4-dihydro-4-oxo-3-chinolincarbonsäure

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Über diesen Artikel

Empirische Formel (Hill-System):
C19H22F2N4O3
CAS-Nummer:
110871-86-8
Molekulargewicht:
392.40
UNSPSC Code:
51282944
NACRES:
NA.85
PubChem Substance ID:
57651613
MDL number:
MFCD00869619
Beilstein/REAXYS Number:
9170271

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Produktname

Sparfloxacin, ≥98.0% (HPLC)

InChI

1S/C19H22F2N4O3/c1-8-5-24(6-9(2)23-8)17-13(20)15(22)12-16(14(17)21)25(10-3-4-10)7-11(18(12)26)19(27)28/h7-10,23H,3-6,22H2,1-2H3,(H,27,28)/t8-,9+

SMILES string

C[C@H]1CN(C[C@@H](C)N1)c2c(F)c(N)c3C(=O)C(=CN(C4CC4)c3c2F)C(O)=O

InChI key

DZZWHBIBMUVIIW-DTORHVGOSA-N

biological source

synthetic

assay

≥98.0% (HPLC)

form

powder

color

white to light yellow

antibiotic activity spectrum

Gram-negative bacteria
Gram-positive bacteria
mycobacteria
mycoplasma

mode of action

enzyme | inhibits

Gene Information

human ... KCNH1(3756), TOP2A(7153)

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1 of 4

Dieser Artikel
N989033899Y0001301
Sparfloxacin ≥98.0% (HPLC)

Sigma-Aldrich

56968

Sparfloxacin

Norfloxacin analytical standard, ≥98% (TLC)

Supelco

N9890

Norfloxacin

Norfloxacin VETRANAL®, analytical standard

Supelco

33899

Norfloxacin

Norfloxacin für die Peakidentifizierung European Pharmacopoeia (EP) Reference Standard

Y0001301

Norfloxacin für die Peakidentifizierung

mode of action

enzyme | inhibits

mode of action

-

mode of action

-

mode of action

-

antibiotic activity spectrum

Gram-negative bacteria, mycobacteria, Gram-positive bacteria, mycoplasma

antibiotic activity spectrum

-

antibiotic activity spectrum

-

antibiotic activity spectrum

-

form

powder

form

-

form

-

form

-

assay

≥98.0% (HPLC)

assay

≥98% (TLC)

assay

-

assay

-

biological source

synthetic

biological source

-

biological source

-

biological source

-

Gene Information

human ... KCNH1(3756), TOP2A(7153)

Gene Information

human ... CYP1A2(1544)
rat ... Gabra1(29705)

Gene Information

-

Gene Information

-

Application

Sparfoxacin is used to study antimicrobial activity against Mycobacteria and respiratory tract infections [1][2].

Biochem/physiol Actions

Sparfloxacin fluoroquinolone antibiotic that inhibits bacterial DNA gyrase (topoisomerase II) and/or topoisomerase IV. It inhibits bacterial DNA gyrase-dependent processes such as DNA polymerization, ATP-dependent-DNA supercoiling, and chromosome fragmentation.

Other Notes

Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.Storage class (TRGS 510): Non Combustible Solids

Packaging

1g, 10g

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Lagerklasse

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

Hier finden Sie alle aktuellen Versionen:

Analysenzertifikate (COA)

Lot/Batch Number
0000227596
0000227595
0000227596
0000227595
0000205322

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Die Dokumentenbibliothek aufrufen

K L Goa et al.
Drugs, 53(4), 700-725 (1997-04-01)
Sparfloxacin is a fluoroquinolone antibacterial agent with activity against a broad range of Gram-negative and Gram-positive organisms including Streptococcus pneumoniae, one of the main pathogens in community-acquired pneumonia. In this infection, sparfloxacin has shown efficacy similar to that of amoxicillin
N Rastogi et al.
Antimicrobial agents and chemotherapy, 35(12), 2473-2480 (1991-12-01)
The MICs and MBCs of the new difluorinated quinolone drug sparfloxacin against type strains belonging to 21 species of mycobacteria were screened. The MICs and MBCs were within the range of 0.1 to 2.0 and 0.1 to 4.0 micrograms/ml, respectively
Radha K Shandil et al.
Antimicrobial agents and chemotherapy, 51(2), 576-582 (2006-12-06)
Members of the fluoroquinolone class are being actively evaluated for inclusion in tuberculosis chemotherapy regimens, and we sought to determine the best in vitro and pharmacodynamic predictors of in vivo efficacy in mice. MICs for Mycobacterium tuberculosis H37Rv were 0.1
Chengxin Zhi et al.
Journal of medicinal chemistry, 49(4), 1455-1465 (2006-02-17)
Novel Gram-positive (Gram+) antibacterial compounds consisting of a DNA polymerase IIIC (pol IIIC) inhibitor covalently connected to a topoisomerase/gyrase inhibitor are described. Specifically, 3-substituted 6-(3-ethyl-4-methylanilino)uracils (EMAUs) in which the 3-substituent is a fluoroquinolone moiety (FQ) connected by various linkers were
Joëlle Azéma et al.
Bioorganic & medicinal chemistry, 17(15), 5396-5407 (2009-07-15)
Ciprofloxacin (CP), an antibiotic has been shown to have antiproliferative and apoptotic activities in several cancer cell lines. Moreover, several reports have highlighted the interest of increasing the lipophilicity to improve the antitumor efficacy. These studies have led us to
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