Direkt zum Inhalt

AS2077715: a novel antifungal antibiotic produced by Capnodium sp. 339855.

AS2077715: a novel antifungal antibiotic produced by Capnodium sp. 339855.

The Journal of antibiotics (2014-05-29)

Keisuke Ohsumi, Teruhisa Masaki, Shigehiro Takase, Masato Watanabe, Akihiko Fujie

ZUSAMMENFASSUNG

A novel antifungal agent, AS2077715, was isolated from the fermentation broth of a fungal strain (339855) identified as a new Capnodium species based on morphological characteristics and large-subunit ribosomal DNA sequencing. AS2077715 was isolated as a white powder via solvent extraction, HP-20 and ODS-B column chromatography and crystallization, and was determined to have the molecular formula C25H41NO7. AS2077715 has a structure related to that of funiculosin, an inhibitor of mitochondrial cytochrome bc1 complex (complex III), and showed antifungal activity against Trichophyton species.

MATERIALIEN

Produktnummer

Marke

Produktbeschreibung

Sigma-Aldrich

Acetonitril, suitable for HPLC, gradient grade, ≥99.9%

Sigma-Aldrich

Methanol, suitable for HPLC, ≥99.9%

Sigma-Aldrich

Dimethylsulfoxid, Hybri-Max^™, sterile-filtered, BioReagent, suitable for hybridoma, ≥99.7%

Sigma-Aldrich

Dimethylsulfoxid, ACS reagent, ≥99.9%

Sigma-Aldrich

Methanol, ACS reagent, ≥99.8%

Sigma-Aldrich

Dimethylsulfoxid, Molecular Biology

Sigma-Aldrich

Dimethylsulfoxid, suitable for HPLC, ≥99.7%

Sigma-Aldrich

Ethylacetat, ACS reagent, ≥99.5%

Sigma-Aldrich

Acetonitril, HPLC Plus, ≥99.9%

Sigma-Aldrich

Dimethylsulfoxid, sterile-filtered, BioPerformance Certified, meets EP, USP testing specifications, suitable for hybridoma

Sigma-Aldrich

Ethylacetat, suitable for HPLC, ≥99.7%

Sigma-Aldrich

Chloroform, contains 100-200 ppm amylenes as stabilizer, ≥99.5%

Sigma-Aldrich

Dimethylsulfoxid, ReagentPlus^®, ≥99.5%

Sigma-Aldrich

Dimethylsulfoxid, anhydrous, ≥99.9%

Sigma-Aldrich

Methanol, HPLC Plus, ≥99.9%

Sigma-Aldrich

Chloroform, HPLC Plus, for HPLC, GC, and residue analysis, ≥99.9%, contains amylenes as stabilizer

Sigma-Aldrich

Ethylacetat, HPLC Plus, for HPLC, GC, and residue analysis, 99.9%

Sigma-Aldrich

Acetonitril, ACS reagent, ≥99.5%

Sigma-Aldrich

Chloroform, contains ethanol as stabilizer, ACS reagent, ≥99.8%

Sigma-Aldrich

Chloroform, suitable for HPLC, ≥99.8%, contains 0.5-1.0% ethanol as stabilizer

Sigma-Aldrich

Acetonitril, anhydrous, 99.8%

Sigma-Aldrich

Dimethylsulfoxid, ≥99.5% (GC), suitable for plant cell culture

Sigma-Aldrich

Methanol, anhydrous, 99.8%

Sigma-Aldrich

Acetonitril, suitable for HPLC, gradient grade, ≥99.9%

Sigma-Aldrich

Methanol, Laboratory Reagent, ≥99.6%

Sigma-Aldrich

Methanol, suitable for HPLC, gradient grade, suitable as ACS-grade LC reagent, ≥99.9%

Sigma-Aldrich

Methanol, ACS spectrophotometric grade, ≥99.9%

Sigma-Aldrich

Chloroform, contains amylenes as stabilizer, ACS reagent, ≥99.8%

Sigma-Aldrich

Dimethylsulfoxid, BioUltra, Molecular Biology, ≥99.5% (GC)

Sigma-Aldrich

Methanol, ACS reagent, ≥99.8%