B6060

BVT.948

≥98% (HPLC), solid

• Sinônimo(s): 4-Hydroxy-3,3-dimethyl-2H-benzo[g]indole-2,5(3H)-dione
• Fórmula empírica (Notação de Hill): C₁₄H₁₁NO₃
• Número CAS: 39674-97-0
• Peso molecular: 241.24
• NACRES: NA.77
• PubChem Substance ID: 24724422
• UNSPSC Code: 12352200
• MDL number: MFCD00616487
• Assay: ≥98% (HPLC)
• Form: solid
• Storage condition: desiccated, protect from light, under inert gas

Propriedades

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: solid
• storage condition: desiccated, protect from light, under inert gas
• color: red
• solubility: DMSO: 18 mg/mL, H₂O: insoluble
• storage temp.: −20°C
• SMILES string: CC1(C)C(=O)N=C2c3ccccc3C(=O)C(O)=C12
• InChI: 1S/C14H11NO3/c1-14(2)9-10(15-13(14)18)7-5-3-4-6-8(7)11(16)12(9)17/h3-6,17H,1-2H3
• InChI key: BAQXWJQSUXZVIP-UHFFFAOYSA-N

Descrição

Biochem/physiol Actions

BVT.948 is a non-competitive inhibitor of protein tyrosine phosphatase (PTP). Enhances insulin signaling in cells and inhibits several cytochrome P450 isoforms in vitro.

Features and Benefits

BVT.948 is a non-competitive inhibitor of protein tyrosine phosphatase (PTP). Enhances insulin signaling in cells and inhibits several cytochrome P450 isoforms in vitro. Works through a different mechanism then the other PTP inhibitors. BVT.948 was able to enhance insulin signaling in cells, although it did not increase tyrosine phosphorylation globally. Furthermore, the compound was active in vivo, enhancing insulin tolerance tests in ob/ob mice, therefore apparently enhancing insulin sensitivity. BVT.948 was able to inhibit several other PTPs tested and also was efficient at inhibiting several cytochrome P450 isoforms in vitro.

Informações de segurança

• Pictogramas: GHS07
• Palavra de aviso: Warning
• Códigos de risco: H317
• Declarações de precaução: P261 - P272 - P280 - P302 + P352 - P333 + P313 - P362 + P364
• Hazard Classifications: Skin Sens. 1
• Classe de armazenamento: 11 - Combustible Solids
• O que está acontecendo?: WGK 3
• Ponto de inflamação (°F): Not applicable
• Ponto de inflamação (°C): Not applicable
• EPI (equipamento de proteção individual): dust mask type N95 (US), Eyeshields, Faceshields, Gloves