The concentration in milligrams per milliliter (mg/mL) depends on the lot. For C8554, which comes in 50 IU per vial, if the specific activity is 5807 IU/mg as indicated in the CoA, dividing this number by 50 IU yields a mass of 8.6 µg. With 1 mL, the concentration would be 8.6 µg/mL.
C8554
Gonadotrofina coriônica
lyophilized powder, suitable for mouse embryo cell culture
Sinônimo(s):
Coriogonina, HCG
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| Tamanho/SKU | Disponibilidade | Preço |
|---|---|---|
50 I.U. | Disponível para enviar em10 de outubro de 2026deCajamar | R$ 737,00 |
Sobre este item
Biological source:
human urine
Form:
lyophilized powder
Assistência Técnica
Precisa de ajuda? Nossa equipe de cientistas experientes está à sua disposição.
Estamos aqui para ajudarbiological source
human urine
Quality Segment
sterility
aseptically processed
form
lyophilized powder
potency
≥5,000 I.U. per mg
mol wt
37.9 kDa, apparent mol wt 37.9 kDa by SDS-PAGE
drug control
Home Office Schedule 4.2
technique(s)
cell culture | embryo: suitable
impurities
HBV,HCV and HIV, tested negative
solubility
H2O: 1 mL/vial, saline: 1 mL/vial
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
Gene Information
human ... CGA(1081)
General description
O hormônio da glicoproteína consiste de uma cadeia α de 92 aminoácidos idêntica à do LH, FSH e TSH; e uma cadeia β distinta de 149 aminoácidos. Produzido por tecido coriônico e responsável pela manutenção do corpo lúteo durante o início da gravidez. Também produzido por neoplasias trofoblásticas, que são caracterizadas por elevado número de cadeias β de hCG livres e hCG hiperglicosilado.
Note: Actual molecular weight will vary from the theoretical depending upon the degree of glycosylation. Theoretical MW is 37.9 kDa based on native form which contains 2 subunits: α = 14.9 kDa (~10.2 kDa for the polypeptide and ~4.7 kDa for the carbohydrate), and β = 23.0 kDa (~16.0 kDa for the polypeptide and ~7.0 kDa for the carbohydrate). See J. Biol. Chem. 248, 6796-6827 (1973).
Application
Recommended for superovulation induction in mice.
Biochem/physiol Actions
Human chorionic gondadotropin (hCG) may be used as an alternative to PMSG to induce ovulation in laboratory animals. When hCG was injected into laboratory animals via intravenous (i.v.), intraperitoneal (i.p.), or subcutaneous (s.c.) methodstet, the effective dose values for 50% of the animals (ED50) per animal and per body weight (kg) in parenthesis were as follows:
Mice: i.v. 0.2 (7.7) I.U.; i.p. 0.3 (11.5) I.U.; s.c. 0.7 (26.9) I.U.
Syrian hamsters: i.v. 1.0 (9.5) I.U.; i.p. 1.8 (17.1) I.U.; s.c. 2.6 (24.8) I.U.
Rats: i.v. 1.3 (4.6) I.U.; i.p. 3.5 (12.3) I.U.; s.c.7.5 (26.3) I.U.
Using PMSG, the ED50 values per animal and per body weight (kg) in parenthesis were as follows:
Mice: i.v. 0.8 (30.8) I.U.; i.p. 2.0 (76.9) I.U.; s.c. 2.8 (107.7) I.U
Syrian hamsters: i.v., 3.6 (34.3) I.U.; i. p., 8.0 (76.2) I.U.; s.c., 13.2 (125.7) I.U.
Rats: i.v., 6.0 (76.8) I.U.; i p., 20.8 (73.0) I.U.; s.c., 76.8 (269.5) I.U.
Mice: i.v. 0.2 (7.7) I.U.; i.p. 0.3 (11.5) I.U.; s.c. 0.7 (26.9) I.U.
Syrian hamsters: i.v. 1.0 (9.5) I.U.; i.p. 1.8 (17.1) I.U.; s.c. 2.6 (24.8) I.U.
Rats: i.v. 1.3 (4.6) I.U.; i.p. 3.5 (12.3) I.U.; s.c.7.5 (26.3) I.U.
Using PMSG, the ED50 values per animal and per body weight (kg) in parenthesis were as follows:
Mice: i.v. 0.8 (30.8) I.U.; i.p. 2.0 (76.9) I.U.; s.c. 2.8 (107.7) I.U
Syrian hamsters: i.v., 3.6 (34.3) I.U.; i. p., 8.0 (76.2) I.U.; s.c., 13.2 (125.7) I.U.
Rats: i.v., 6.0 (76.8) I.U.; i p., 20.8 (73.0) I.U.; s.c., 76.8 (269.5) I.U.
1 of 1
Este Item | |||
|---|---|---|---|
| description lyophilized powder, suitable for mouse embryo cell culture | description lyophilized powder, vial of ~5,000 IU | description lyophilized powder, vial of ~2,500 IU | description lyophilized powder, vial of ~10,000 IU |
| biological source human urine | biological source human urine | biological source human urine | biological source human urine |
| Quality Level 200 | Quality Level 200 | Quality Level 200 | Quality Level 200 |
| form lyophilized powder | form lyophilized powder | form lyophilized powder | form lyophilized powder |
| technique(s) cell culture | embryo: suitable | technique(s) - | technique(s) - | technique(s) - |
| storage temp. −20°C | storage temp. −20°C | storage temp. −20°C | storage temp. −20°C |
| solubility H2O: 1 mL/vial, saline: 1 mL/vial | solubility water: 10 mL/vial, clear to slightly hazy, colorless | solubility water: 10 mL/vial, clear, colorless | solubility water: 10 mL/vial, clear to slightly hazy, colorless |
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