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Merck

O7885

Okadaic acid potassium salt from Prorocentrum concavum

≥90% (HPLC), powder

Sinônimo(s):

OA

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Sobre este item

Fórmula empírica (Notação de Hill):
C44H67KO13
Número CAS:
Peso molecular:
843.09
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352106
MDL number:
Assay:
≥90% (HPLC)
Form:
powder
Quality level:
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Precisa de ajuda? Nossa equipe de cientistas experientes está à sua disposição.
Estamos aqui para ajudar

Nome do produto

Okadaic acid potassium salt from Prorocentrum concavum, ≥90% (HPLC), powder

InChI

1S/C46H72O13.K/c1-27-20-35(56-46(22-27)36(48)12-15-42(7,59-46)24-43(8,52)40(50)51)28(2)10-14-41(6)17-18-45(58-41)16-11-34-39(57-45)37(49)30(4)38(55-34)33(47)21-29(3)32-23-44(26-54-31(32)5)13-9-19-53-25-44;/h10,14,22,28-29,31-39,47-49,52H,4,9,11-13,15-21,23-26H2,1-3,5-8H3,(H,50,51);/q;+1/p-1/b14-10+;

SMILES string

[K+].CC(CC(O)C1OC2CCC3(CCC(C)(O3)\C=C\C(C)C4CC(C)=CC5(O4)OC(C)(CCC5O)CC(C)(O)C([O-])=O)OC2C(O)C1=C)C6CC7(CCCOC7)COC6C

InChI key

CWKZDWKRECTBCU-KMZJGFRYSA-M

biological source

plant (Prorocentrum concavum)

assay

≥90% (HPLC)

form

powder

color

white

solubility

H2O: 0.1 mg/mL
DMSO: soluble
ethanol: soluble

storage temp.

−20°C

Quality Level

Biochem/physiol Actions

Dinoflagellate toxin and an ionophore-like polyether derivative of a 38 carbon, fatty acid. Readily enters cells. Inhibitor of type 1 and type 2A protein phosphatases. Does not inhibit tyrosine phosphatases, alkaline phosphatases or acid phosphatase. Known tumor promotor. Used to study various cellular processes including cell cycle, apoptosis, nitric oxide metabolism and calcium signaling.
Okadaic acid is a dinoflagellate toxin and an ionophore-like polyether derivative of a 38 carbon, fatty acid.

pictograms

Skull and crossbones

signalword

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Skin Irrit. 2

Classe de armazenamento

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges


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Mitchell J George et al.
International journal of molecular sciences, 22(12) (2021-07-03)
Myosin Light Chain (MLC) regulates platelet contraction through its phosphorylation by Myosin Light Chain Kinase (MLCK) or dephosphorylation by Myosin Light Chain Phosphatase (MLCP). The correlation between platelet contraction force and levels of MLC phosphorylation is unknown. We investigate the
Yulan Zhao et al.
Life sciences, 246, 117382-117382 (2020-02-01)
Our preliminary research revealed that metformin, a classic anti-diabetic drug, could rescue Parkin protein expression and mitophagy in high glucose-challenged human renal epithelial cells in vitro, but the molecular mechanism remains to be explored. In the study, Human Renal Cortical
Huijing Yin et al.
Nature communications, 12(1), 4230-4230 (2021-07-11)
Extracellular matrix protein-1 (ECM1) promotes tumorigenesis in multiple organs but the mechanisms associated to ECM1 isoform subtypes have yet to be clarified. We report in this study that the secretory ECM1a isoform induces tumorigenesis through the GPR motif binding to
Yongqiang Chen et al.
Autophagy, 18(6), 1274-1296 (2021-09-18)
Cancer cell growth is dependent upon the sustainability of proliferative signaling and resisting cell death. Macroautophagy/autophagy promotes cancer cell growth by providing nutrients to cells and preventing cell death. This is in contrast to autophagy promoting cell death under some
Chris M Brewer et al.
Developmental cell, 56(19), 2722-2740 (2021-10-06)
Spiny mice (Acomys cahirinus) are terrestrial mammals that evolved unique scar-free regenerative wound-healing properties. Myofibroblasts (MFs) are the major scar-forming cell type in skin. We found that following traumatic injury to ear pinnae, MFs appeared rapidly in both Acomys and

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