SML2425

Manidipine hydrochloride

≥98% (HPLC)

• Sinônimo(s): 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid hydrchloride, 2-[4-(diphenylmethyl)-1-piperazinyl]ethyl methyl ester, 3-(2-(4-Benzhydrylpiperazin-1-yl)ethyl) 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate hydrchloride, CV 4093 hydrchloride, CV-4093 hydrchloride, CV4093 hydrchloride, Franidipine hydrchloride, Manidipine 6300 hydrchloride
• Fórmula empírica (Notação de Hill): C₃₅H₃₈N₄O₆ · xHCl
• Número CAS: 257288-11-2
• Peso molecular: 610.70 (free base basis)
• UNSPSC Code: 12352200
• NACRES: NA.77
• MDL number: MFCD00871291
• Assay: ≥98% (HPLC)
• Form: powder
• Storage condition: desiccated

Propriedades

• assay: ≥98% (HPLC)
• form: powder
• storage condition: desiccated
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear (warmed)
• storage temp.: 2-8°C

Descrição

Biochem/physiol Actions

Dihydropyridine class calcium channel blocker (CCB) that exerits its antihypertensive activity via targeting both L-type and T-type calcium channels.

Manidipine is a dihydropyridine class calcium channel blocker (CCB) that exerits its antihypertensive activity via targeting both L-type and T-type calcium channels. In contrary to other dihydropyridines and non-dihydropyridines that mainly act as L-type CCBs, Manidipine diminishes glomerular pressure and, consequently, albumin excretion via its action against T-type channels of efferent arterioles in addition to promoting afferent arteriole dilation by blocking L-type channels. Clinically, Manidipine is as effective in lowering blood pressure as other dihydropyridines, while only Manidipine significantly reduces albuminuria and insulin resistance with less adverse effects. In obese and hypertensive individuals, Manidipine is more effective than Lercanidipine in reducing insulin resistance, while Nifedipine treatment is reported to increase insulin desensitisation.

Informações de segurança

• Pictogramas: GHS06
• Palavra de aviso: Danger
• Códigos de risco: H301,H336
• Declarações de precaução: P261 - P264 - P271 - P301 + P310 - P304 + P340 + P312 - P403 + P233
• Hazard Classifications: Acute Tox. 3 Oral - STOT SE 3
• Órgãos-alvo: Central nervous system
• Classe de armazenamento: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• O que está acontecendo?: WGK 3
• Ponto de inflamação (°F): Not applicable
• Ponto de inflamação (°C): Not applicable