P186

PD 123,319 di(trifluoroacetate) salt hydrate

≥98% (HPLC), angiotensin II subtype-2 receptor antagonist, powder

• Synonym(e): S-(+)-1-[(4-(Dimethylamino)-3-methylphenyl)methyl]-5-(diphenylacetyl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid di(trifluoroacetate) salt hydrate
• Empirische Formel (Hill-System): C₃₁H₃₂N₄O₃ · 2C₂HF₃O₂ · xH₂O
• CAS-Nummer: 136676-91-0
• Molekulargewicht: 736.66 (anhydrous basis)
• UNSPSC Code: 12352202
• PubChem Substance ID: 24898250
• NACRES: NA.32
• MDL number: MFCD11046022
• Assay: ≥98% (HPLC)
• Form: powder
• Storage condition: desiccated

Eigenschaften

• Produktname: PD 123,319 di(trifluoroacetate) salt hydrate, powder, ≥98% (HPLC)
• assay: ≥98% (HPLC)
• form: powder
• storage condition: desiccated
• solubility: H₂O: 10 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: O.OC(=O)C(F)(F)F.OC(=O)C(F)(F)F.CN(C)c1ccc(Cn2cnc3CN([C@@H](Cc23)C(O)=O)C(=O)C(c4ccccc4)c5ccccc5)cc1C
• InChI: 1S/C31H32N4O3.2C2HF3O2.H2O/c1-21-16-22(14-15-26(21)33(2)3)18-34-20-32-25-19-35(28(31(37)38)17-27(25)34)30(36)29(23-10-6-4-7-11-23)24-12-8-5-9-13-24;2*3-2(4,5)1(6)7;/h4-16,20,28-29H,17-19H2,1-3H3,(H,37,38);2*(H,6,7);1H2/t28-;;;/m0.../s1
• InChI key: PTSUEYBWHKDYBS-FPCIESGBSA-N

Beschreibung

Application

PD123,319 di (trifluoroacetate) salt hydrate has been used in following experimental studies:

• To determine the effect of Angiotensin II (Ang II) on alveolar fluid clearance (AFC).
• To study the effect of PD123319 on AngII-induced abdominal aortic aneurysms (AAAs).
• To study its effect on Ang II-induced LRP1 overexpression and function in vascular smooth muscle cells (VSMCs) culture.

Biochem/physiol Actions

PD123,319 di (trifluoroacetate) salt hydrate is a widely used angiotensin II subtype-2 receptor (AT2R) antagonist to study the role of AT2 receptor in vitro and in vivo. It increases the AngII-induced abdominal aortic aneurysms (AAAs) without interacting with AT2 receptor.

Disclaimer

Hygroscopic

Sicherheitshinweise

• pictograms: GHS07
• signalword: Warning
• hcodes: H315,H319,H335
• pcodes: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• target_organs: Respiratory system
• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves