SML2000

3-BrOP

≥98% (GC)

• Synonym(e): 3-BrPA propyl ester, 3-Bromo-2-oxopropionate-1-propyl ester, 3-Bromopyruvate propyl ester, Glycolycin, Propyl 3-bromo-2-oxopropanoate
• Empirische Formel (Hill-System): C₆H₉BrO₃
• CAS-Nummer: 629659-95-6
• Molekulargewicht: 209.04
• UNSPSC Code: 12352200
• Assay: ≥98% (GC)
• Form: oil

Eigenschaften

• assay: ≥98% (GC)
• form: oil
• color: colorless to yellow
• shipped in: ambient
• storage temp.: 2-8°C

Beschreibung

Biochem/physiol Actions

3-BrOP is a cell-permeable ester of the the glycolysis inhibitor 3-bromopyruvate (3-BrPA) that is known to target hexokinase II (HK2) and GAPDH. Upon entering the cells, 3-BrOP is hydrolyzed by intracellular esterase to 3-BrPA. 3-BrOP is shown to synergize cancer cell killing with mTOR inhibitor rapamycin (apoptosis induction with/without 100 ng/mL rapamycin = 64%/36% of Raji human lymphoma cells by 40 μM 3-BrOP and 72%/45% of HL-60 leukemia cells by 20 μM 3-BrOP in 24 h) due to enhanced cellular ATP depletion and glucose uptake inhibition. When administered via tail vein injection, 3-BrOP significantly suppersses SK-N-SH xenograft-derived neuroblastoma tumor growth in mice in vivo (by 78% in 14 days; 20 mg/kg/day).

Cell-permeable ester of the the glycolysis inhibitor 3-bromopyruvate (3-BrPA) with in vitro and in vivo anti-cancer efficacy.

Sicherheitshinweise

• signalword: Warning
• pictograms: GHS07
• hcodes: H315,H319,H335
• pcodes: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• target_organs: Respiratory system
• Lagerklasse: 10 - Combustible liquids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable