SML2267

GeA-69

≥98% (HPLC)

• Synonym(e): N-[2-(9H-Carbazol-1-yl)phenyl]-acetamide
• Empirische Formel (Hill-System): C₂₀H₁₆N₂O
• CAS-Nummer: 2143475-98-1
• Molekulargewicht: 300.35
• UNSPSC Code: 12352200
• NACRES: NA.77
• eCl@ss: 32150313
• Assay: ≥98% (HPLC)
• Form: powder

Eigenschaften

• assay: ≥98% (HPLC)
• form: powder
• color: off-white to brown
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: CC(NC1=CC=CC=C1C2=CC=CC3=C2NC4=CC=CC=C43)=O
• InChI key: LDPDVNYCIOHPGF-UHFFFAOYSA-N

Beschreibung

Biochem/physiol Actions

GeA-69 is a selective allosteric inhibitor of macrodomain 2 of poly-adenosine-diphosphate-ribose polymerase 14 (PARP14), an anti-apoptotic pro-survival protein associated with inflammatory diseases and several types of cancer. GeA-69 exhibited a KD of 860 nM in ITC experiments. GeA-69 was shown to be an allosteric inhibitor of adenosine diphosphate ribose (ADPR) binding to PARP14 macrodomain 2 and to prevent recruitment of the PAPP14 macrodomain 2 to DNA damage sites.

Selective allosteric inhibitor of PARP14 macrodomain 2

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable