If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
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For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf
C0378
Cloramfenicolo
≥98% (HPLC)
Sinonimo/i:
D-(−)-treo-2,2-dicloro-N-[β-idrossi-α-(idrossimetil)-β-(4-nitrofenil)etil]acetammide, D-(−)-treo-2-dicloroacetammido-1-(4-nitrofenil)-1,3-propanediolo, D-treo-2,2-dicloro-N-[β-idrossi-α-(idrossimetil)-4-nitrofenetil]acetammide, Cloromicetina
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CHF 43.00
CHF 75.90
CHF 260.00
CHF 885.00
CHF 1’450.00
Informazioni su questo articolo
Vai a
Saggio
≥98% (HPLC)
Stato
powder or crystals
pKa
5.5
Punto di fusione
149-153 °C (lit.)
Spettro attività antibiotica
Gram-negative bacteria
Gram-positive bacteria
mycobacteria
mycoplasma
Modalità d’azione
protein synthesis | interferes
Temperatura di conservazione
room temp
Stringa SMILE
OC[C@@H](NC(=O)C(Cl)Cl)[C@H](O)c1ccc(cc1)[N+]([O-])=O
InChI
1S/C11H12Cl2N2O5/c12-10(13)11(18)14-8(5-16)9(17)6-1-3-7(4-2-6)15(19)20/h1-4,8-10,16-17H,5H2,(H,14,18)/t8-,9-/m1/s1
WIIZWVCIJKGZOK-RKDXNWHRSA-N
Informazioni sul gene
human ... CYP1A2(1544)
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Categorie correlate
1 of 4
Questo articolo | C1919 | 31667 | Y0001869 |
|---|---|---|---|
| antibiotic activity spectrum Gram-negative bacteria, mycobacteria, Gram-positive bacteria, mycoplasma | antibiotic activity spectrum Gram-negative bacteria, Gram-positive bacteria, mycobacteria, mycoplasma | antibiotic activity spectrum - | antibiotic activity spectrum - |
| mode of action protein synthesis | interferes | mode of action protein synthesis | interferes | mode of action - | mode of action - |
| Quality Level 200 | Quality Level 200 | Quality Level 100 | Quality Level - |
| assay ≥98% (HPLC) | assay - | assay ≥98% (HPLC) | assay - |
| form powder or crystals | form powder | form - | form - |
| storage temp. room temp | storage temp. 2-8°C | storage temp. - | storage temp. 2-8°C |
Descrizione generale
Applicazioni
Il cloramfenicolo è stato utilizzato come antibiotico batteriostatico non potente.[1] È stato adoperato per la selezione/crescita di cellule batteriche positive.[2][3]
Azioni biochim/fisiol
Modalità di resistenza: l′uso della cloramfenicolo acetiltransferasi acetila il prodotto e lo inattiva.
Spettro antimicrobico: questo è un antibiotico ad ampio spettro contro batteri gram positivi e gram negativi e viene utilizzato principalmente per scopi oftalmici e veterinari.
Nota sulla preparazione
Altre note
Esclusione di responsabilità
Avvertenze
Danger
Indicazioni di pericolo
Consigli di prudenza
Classi di pericolo
Carc. 2 - Eye Dam. 1 - Repr. 2
Codice della classe di stoccaggio
11 - Combustible Solids
Classe di pericolosità dell'acqua (WGK)
WGK 3
Dispositivi di protezione individuale
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
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Protocolli
Preparation of Plasmid DNA by Alkaline Lysis with SDS: Maxipreparation between Cold Spring Harbor Laboratory Press and our research team.
To measure chloramphenicol acetyltransferase activity, this procedure uses DTNB and coenzyme A. The reaction of DTNB with the –SH group on CoA results in a colorimetric increase at 412 nm.
Contenuto correlato
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How can I determine the shelf life / expiration / retest date of this product?
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Was the pKa determined experimentally, or is it based on data from the literature? If the value is from the literature, please provide the source.
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The value comes from literature. Two references that cite this value are:
Georgeta-Simona Stan, Irinel Adriana Badea, Hassan Y. Aboul-Enein, HPLC Method for Quantification of Five Compounds in a Parenteral Form Used in Treatment of Companion Animals, Journal of Chromatographic Science, Volume 54, Issue 9, 17 October 2016, Pages 1567–1572, https://doi.org/10.1093/chromsci/bmw105
Engesland, A., Škalko-Basnet, N., & Flaten, G. E. (2016). In vitro models to estimate drug penetration through the compromised stratum corneum barrier. Drug Development and Industrial Pharmacy, 42(11), 1742–1751. https://doi.org/10.3109/03639045.2016.1171334
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How is shipping temperature determined? And how is it related to the product storage temperature?
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Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf
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