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Merck

S9137

Streptomicina

powder, BioReagent, suitable for cell culture

Sinonimo/i:

Streptomycin, Streptomycin Sulphate

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25 G

CHF 84.00

100 G

CHF 246.00

CHF 84.00


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Informazioni su questo articolo

Formula condensata:
C21H39N7O12 · 1.5 H2SO4
Numero CAS:
Peso molecolare:
728.69
Beilstein:
3894995
Numero CE:
Numero MDL:
Codice UNSPSC:
51281675
ID PubChem:
NACRES:
NA.76

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Nome Commerciale

BioReagent

Livello qualitativo

Stato

powder

Potenza

≥720 I.U. per mg (dried basis)

Condizioni di stoccaggio

(Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.)

tecniche

cell culture | mammalian: suitable

Colore

white to off-white

Spettro attività antibiotica

Gram-negative bacteria
Gram-positive bacteria
mycobacteria

Modalità d’azione

protein synthesis | interferes

Temperatura di conservazione

2-8°C

Stringa SMILE

OS(O)(=O)=O.OS(O)(=O)=O.OS(O)(=O)=O.CN[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@H]2[C@@H](O[C@@H](C)[C@]2(O)C=O)O[C@@H]3[C@@H](O)[C@H](O)[C@@H](NC(N)=N)[C@H](O)[C@H]3NC(N)=N.CN[C@H]4[C@H](O)[C@@H](O)[C@H](CO)O[C@H]4O[C@H]5[C@@H](O[C@@H](C)[C@]5(O)C=O)O[C@@H]6[C@@H](O)[C@H](O)[C@@H](NC(N)=N)[C@H](O)[C@H]6NC(N)=N

InChI

1S/2C21H39N7O12.3H2O4S/c2*1-5-21(36,4-30)16(40-17-9(26-2)13(34)10(31)6(3-29)38-17)18(37-5)39-15-8(28-20(24)25)11(32)7(27-19(22)23)12(33)14(15)35;3*1-5(2,3)4/h2*4-18,26,29,31-36H,3H2,1-2H3,(H4,22,23,27)(H4,24,25,28);3*(H2,1,2,3,4)/t2*5-,6-,7-,8+,9-,10-,11-,12+,13-,14-,15-,16-,17-,18-,21+;;;/m00.../s1
QTENRWWVYAAPBI-YZTFXSNBSA-N

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Questo articolo
S1277S650185886
Streptomicina powder, BioReagent, suitable for cell culture

Sigma-Aldrich

S9137

Streptomicina

Streptomicina powder, BioXtra, suitable for mouse embryo cell culture

Sigma-Aldrich

S1277

Streptomicina

Streptomicina powder

Sigma-Aldrich

S6501

Streptomicina

Streptomycin solution ~1 mg/mL in 1 mM EDTA, analytical standard

Supelco

85886

Streptomycin solution

mode of action

protein synthesis | interferes

mode of action

protein synthesis | interferes

mode of action

protein synthesis | interferes

mode of action

protein synthesis | interferes

technique(s)

cell culture | mammalian: suitable

technique(s)

cell culture | embryo: suitable

technique(s)

-

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

antibiotic activity spectrum

Gram-negative bacteria, mycobacteria, Gram-positive bacteria

antibiotic activity spectrum

Gram-negative bacteria, Gram-positive bacteria, mycobacteria

antibiotic activity spectrum

Gram-negative bacteria, Gram-positive bacteria, mycobacteria

antibiotic activity spectrum

Gram-negative bacteria, Gram-positive bacteria, mycobacteria

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

100

product line

BioReagent

product line

BioXtra

product line

-

product line

-

form

powder

form

powder

form

powder

form

liquid

Descrizione generale

Chemical structure: aminoglycoside

Applicazioni

Streptomycin is used to study mechanisms of streptomycin resistance and is often used together with penicillin and other agents to inhibit bacterial contamination in cell culture applications. It is recommended for use in molecular biology applications at 25-50μg/mL, in cell culture applications at 100 mg/L and in embryo culture at 50 mg/L.

Azioni biochim/fisiol

Modalità d′azione: La streptomicina agisce inibendo la sintesi delle proteine dei procarioti legandosi alla proteina S12 della subunità ribosomiale 30S. In questo modo impedisce la transizione da complesso imitativo a ribosoma di allungamento della catena. Ciò causa errori di codifica o inibisce l′avvio.

Modalità di resistenza: Una mutazione in rpsL, un gene per la proteina ribosomiale S12, impedisce il legame della streptomicina con il ribosoma. Inoltre, un′aminoglicoside fosfotransferasi inattiva la streptomicina.

Spettro antimicrobico: La streptomicina è attiva nei confronti dei batteri gram positivi e gram negativi.

Nota sulla preparazione

Stock solutions should be prepared directly in the vial with sterile water at concentrations between 20-25 mg/mL.

Altre note

Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place

Esclusione di responsabilità

Solutions can be stored at 2-8°C for up to a month or at -20°C for more extended periods. At 37°C, solutions are stable for three days.

Pittogrammi

Health hazardExclamation mark

Avvertenze

Warning

Indicazioni di pericolo

Classi di pericolo

Acute Tox. 4 Oral - Repr. 2

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

dust mask type N95 (US), Eyeshields, Faceshields, Gloves


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Questions

1–2 of 2 Questions  
  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf

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  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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