SML2000

3-BrOP

≥98% (GC)

• Synonyme(s) : 3-BrPA propyl ester, 3-Bromo-2-oxopropionate-1-propyl ester, 3-Bromopyruvate propyl ester, Glycolycin, Propyl 3-bromo-2-oxopropanoate
• Formule empirique (notation de Hill) : C₆H₉BrO₃
• Numéro CAS: 629659-95-6
• Poids moléculaire : 209.04
• UNSPSC Code: 12352200
• Assay: ≥98% (GC)
• Form: oil

Propriétés

• assay: ≥98% (GC)
• form: oil
• color: colorless to yellow
• shipped in: ambient
• storage temp.: 2-8°C

Description

Biochem/physiol Actions

3-BrOP is a cell-permeable ester of the the glycolysis inhibitor 3-bromopyruvate (3-BrPA) that is known to target hexokinase II (HK2) and GAPDH. Upon entering the cells, 3-BrOP is hydrolyzed by intracellular esterase to 3-BrPA. 3-BrOP is shown to synergize cancer cell killing with mTOR inhibitor rapamycin (apoptosis induction with/without 100 ng/mL rapamycin = 64%/36% of Raji human lymphoma cells by 40 μM 3-BrOP and 72%/45% of HL-60 leukemia cells by 20 μM 3-BrOP in 24 h) due to enhanced cellular ATP depletion and glucose uptake inhibition. When administered via tail vein injection, 3-BrOP significantly suppersses SK-N-SH xenograft-derived neuroblastoma tumor growth in mice in vivo (by 78% in 14 days; 20 mg/kg/day).

Cell-permeable ester of the the glycolysis inhibitor 3-bromopyruvate (3-BrPA) with in vitro and in vivo anti-cancer efficacy.

Informations sur la sécurité

• Mot-clé: Warning
• Pictogrammes: GHS07
• Codes de danger: H315,H319,H335
• Mentions de précaution: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Organes cibles: Respiratory system
• Classe de stockage: 10 - Combustible liquids
• WGK: WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable