If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf
719897
Resomer® RG 502 H, Poly(D,L-lactide-co-glycolide)
acid terminated, viscosity 0.16-0.24 dL/g
Sinonim:
PLGA
Pilih Ukuran
About This Item
Loncat ke
form
amorphous
feed ratio
lactide:glycolide 50:50
degradation timeframe
<3 months
viscosity
0.16-0.24 dL/g
transition temp
Tg 42-46 °C
storage temp.
2-8°C
SMILES string
O2C(C(=O)OC(C2=O)C)C.O1CC(=O)OCC1=O
InChI
1S/C6H8O4.C4H4O4/c1-3-5(7)10-4(2)6(8)9-3;5-3-1-7-4(6)2-8-3/h3-4H,1-2H3;1-2H2
InChI key
LCSKNASZPVZHEG-UHFFFAOYSA-N
1 of 4
Item ini | 739952 | 719927 | 739979 |
|---|---|---|---|
| viscosity 0.16-0.24 dL/g | viscosity 0.32-0.44 dL/g, 0.1 % (w/v) in chloroform(25 °C, Ubbelohde) (size 0c glass capillary viscometer) | viscosity 0.71-1.0 dL/g, 0.1 % (w/v) in chloroform(25 °C, Ubbelohde) (size 0c glass capillary viscometer) | viscosity 1.3-1.7 dL/g, 0.1 % (w/v) in chloroform(25 °C, Ubbelohde) (size 0c glass capillary viscometer) |
| form amorphous | form amorphous | form amorphous | form amorphous |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C |
| feed ratio lactide:glycolide 50:50 | feed ratio lactide:glycolide 50:50 | feed ratio lactide:glycolide 75:25 | feed ratio lactide:glycolide 85:15 |
| degradation timeframe <3 months | degradation timeframe <3 months | degradation timeframe <6 months | degradation timeframe <9 months |
| transition temp Tg 42-46 °C | transition temp Tg 44-48 °C | transition temp Tg 49-55 °C | transition temp - |
Application
- In the formulation ofa non-aqueous drug delivery system for H2S donors to aid thesustained release of the drug.
- To prepare a polymer blend containing Ganciclovir-loaded microspheresdispersed in PLGA–PEG–PLGA polymer gel. This formulation can be used as asustained delivery system for Ganciclovir drug.
Legal Information
related product
Kelas Penyimpanan
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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How can I determine the shelf life / expiration / retest date of this product?
1 answer-
Helpful?
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Is this material a Pharmaceutical Secondary Standard (Certified Reference Material)?
1 answer-
This product is not a pharmaceutical secondary standard.
Helpful?
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Resomer® RG 502 H, Catalogue No.719897 Q1: Why the Molecular weight of this product is in a range from 7000-17000 and not fixed? Q2: How many COOH groups will be there for each molecule? Q3: Is PLGA made in random or alternative block design?
1 answer-
Q1: The molecular weight range of 7000-17000 is a specification range, and the exact molecular weight is determined on a lot-to-lot basis, as listed on the Certificate of Analysis.
Q2: The number of COOH groups per molecule is not tested. The acid value, which can be referenced, has a specification range of ≥ 6.0 mg KOH/g.
Q3: This product is Poly(D,L-lactide-co-glycolide), where "-co-" indicates an unspecified arrangement. Information on block design is not available, and there is no Poly(D,L-lactide-ran-glycolide) or Poly(D,L-lactide-alt-glycolide) available.
Helpful?
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Qual è il range di pesp molecolare di questo polimero?
1 answer-
The Resomer RG group of products has a molecular weight range of 7000 - 240,000 daltons. The value is lot specific and reported in the product Certificate of Analysis. Please see the link below to review a sample or lot specific Certificate:
https://www.sigmaaldrich.com/product/aldrich/719897#product-documentationHelpful?
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How is shipping temperature determined? And how is it related to the product storage temperature?
1 answer-
Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf
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