主要文書

すべての文書を表示

スキップする

407331

Cpd 22

Name: Cpd 22
Brand: MM

≥94% (HPLC), integrin-linked kinase inhibitor, powder

別名:

ILK inhibitor, Cpd 22

ログインで組織・契約価格をご覧ください。

サイズを選択してください

表示を変更する

サイズ/SKU	在庫状況	単価

この商品について

実験式（ヒル表記法）:

C₃₀H₃₀F₃N₅O

分子量:

533.59

UNSPSC Code:

12352200

NACRES:

NA.77

eCl@ss:

32160702

Assay:

≥94% (HPLC)

Form:

powder

Storage condition:

OK to freeze, protect from light

この製品は、Merck Milliporeウェブサイトでのみ注文できます。

テクニカルサービス

お困りのことがあれば、経験豊富なテクニカルサービスチームがお客様をサポートします。

お手伝いします

特性

製品名

ILK inhibitor, Cpd 22, The ILK inhibitor, Cpd 22 controls the biological activity of ILK. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

Quality Segment

100

assay

≥94% (HPLC)

form

powder

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, protect from light

color

off-white

solubility

DMSO: 100 mg/mL

shipped in

ambient

storage temp.

2-8°C

詳細

General description

A cell-permeable, tri-substituted pyrazol compound that acts as a potent and specific integrin-linked kinase (ILK) inhibitor (IC₅₀ = 600 nM). Shown to have high in vitro anti-proliferative potency against prostrate and breast cancer cell lines (IC₅₀ = 1 to 2.5 µM) while sparing normal epithelial cells. Its effect on cancer cells have been attributed to induction of autophagy and apoptosis. Suppresses ILK-mediated phosphorylation of Akt at Ser473 site, thereby down-regulating the downstream targets, such as GSK-3b and myosin light chain. Also causes a transcriptional repression of the transcription factor Y-Box binding protein 1 (YB-1). Exhibits minimum toxicity in mouse model.

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Lee, S., et al. 2011. J. Med. Chem.54, 6364

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

類似品目との比較

比較内容をすべて表示

相違点を表示

1 of 1

当該品目	HPA048437	I0783	EMU058451
Sigma-Aldrich 407331 ILK inhibitor, Cpd 22	Sigma-Aldrich HPA048437 Anti-ILK antibody produced in rabbit	Sigma-Aldrich I0783 Monoclonal Anti-ILK antibody produced in mouse	Sigma-Aldrich EMU058451 MISSION^® esiRNA
description The ILK inhibitor, Cpd 22 controls the biological activity of ILK. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.	description Prestige Antibodies^® Powered by Atlas Antibodies, affinity isolated antibody	description ~2 mg/mL, clone 65.1, purified immunoglobulin, buffered aqueous solution	description targeting mouse Cpd
assay ≥94% (HPLC)	assay -	assay -	assay -
form powder	form buffered aqueous glycerol solution	form buffered aqueous solution	form lyophilized powder
Quality Level 100	Quality Level 100	Quality Level 200	Quality Level 100
manufacturer/tradename Calbiochem^®	manufacturer/tradename -	manufacturer/tradename -	manufacturer/tradename -
storage temp. 2-8°C	storage temp. −20°C	storage temp. −20°C	storage temp. −20°C
storage condition protect from light, OK to freeze	storage condition -	storage condition -	storage condition -

保管分類

11 - Combustible Solids

WGK

WGK 1

引火点 (F)

Not applicable

引火点（°C）