B6060

BVT.948

≥98% (HPLC), solid

• 別名: 4-Hydroxy-3,3-dimethyl-2H-benzo[g]indole-2,5(3H)-dione
• 実験式（ヒル表記法）: C₁₄H₁₁NO₃
• CAS番号: 39674-97-0
• 分子量: 241.24
• NACRES: NA.77
• PubChem Substance ID: 24724422
• UNSPSC Code: 12352200
• MDL number: MFCD00616487
• eCl@ss: 32150313
• Assay: ≥98% (HPLC)
• Form: solid
• Storage condition: desiccated, protect from light, under inert gas

特性

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: solid
• storage condition: desiccated, protect from light, under inert gas
• color: red
• solubility: DMSO: 18 mg/mL, H₂O: insoluble
• storage temp.: −20°C
• SMILES string: CC1(C)C(=O)N=C2c3ccccc3C(=O)C(O)=C12
• InChI: 1S/C14H11NO3/c1-14(2)9-10(15-13(14)18)7-5-3-4-6-8(7)11(16)12(9)17/h3-6,17H,1-2H3
• InChI key: BAQXWJQSUXZVIP-UHFFFAOYSA-N

詳細

Biochem/physiol Actions

BVT.948 is a non-competitive inhibitor of protein tyrosine phosphatase (PTP). Enhances insulin signaling in cells and inhibits several cytochrome P450 isoforms in vitro.

Features and Benefits

BVT.948 is a non-competitive inhibitor of protein tyrosine phosphatase (PTP). Enhances insulin signaling in cells and inhibits several cytochrome P450 isoforms in vitro. Works through a different mechanism then the other PTP inhibitors. BVT.948 was able to enhance insulin signaling in cells, although it did not increase tyrosine phosphorylation globally. Furthermore, the compound was active in vivo, enhancing insulin tolerance tests in ob/ob mice, therefore apparently enhancing insulin sensitivity. BVT.948 was able to inhibit several other PTPs tested and also was efficient at inhibiting several cytochrome P450 isoforms in vitro.

安全性情報

• ピクトグラム: GHS07
• 注意喚起語: Warning
• ハザードコード: H317
• 注意事項: P261 - P272 - P280 - P302 + P352 - P333 + P313 - P362 + P364
• Hazard Classifications: Skin Sens. 1
• 保管分類: 11 - Combustible Solids
• WGK: WGK 3
• 引火点 (F): Not applicable
• 引火点（°C）: Not applicable
• PPE（個人用保護具）: dust mask type N95 (US), Eyeshields, Faceshields, Gloves