Merck
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C8249

Sigma-Aldrich

カルダモニン

≥98% (HPLC)

Synonym(s):
(2E)-1-(2,4-ジヒドロキシ-6-メトキシフェニル)-3-フェニル-2-プロペン-1-オン, (8CI);アルピネチンカルコン, (E)-2',4'-ジヒドロキシ-6'-メトキシ-カルコン
Empirical Formula (Hill Notation):
C16H14O4
CAS Number:
Molecular Weight:
270.28
MDL番号:
PubChem Substance ID:
NACRES:
NA.77

アッセイ

≥98% (HPLC)

形状

powder

light yellow to dark brown

溶解性

DMSO: ≥20 mg/mL

保管温度

room temp

SMILES string

O=C(/C=C/C1=CC=CC=C1)C2=C(O)C=C(O)C=C2OC

InChI

1S/C16H14O4/c1-20-15-10-12(17)9-14(19)16(15)13(18)8-7-11-5-3-2-4-6-11/h2-10,17,19H,1H3/b8-7+

InChI key

NYSZJNUIVUBQMM-BQYQJAHWSA-N

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This Item
G6657PHL8037969553
Cardamonin ≥98% (HPLC)

Sigma-Aldrich

C8249

カルダモニン

Cardamomin phyproof® Reference Substance

PHL80379

カルダモニン

α-Cryptoxanthin ≥90.0% (HPLC)

Sigma-Aldrich

69553

α-Cryptoxanthin

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98.0% (HPLC)

assay

≥90.0% (HPLC)

form

powder

form

-

form

-

form

solid

color

light yellow to dark brown

color

-

color

-

color

-

solubility

DMSO: ≥20 mg/mL

solubility

H2O: 5 mg/mL (with brief sonication), alcohol: soluble

solubility

-

solubility

-

storage temp.

room temp

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

−20°C

Quality Level

100

Quality Level

200

Quality Level

-

Quality Level

100

アプリケーション

Cardamonin has been used as a glycogen synthase kinase 3 (GSK3) inhibitor to study its effects on β-catenin loss and gain-of-function in human preimplantation embryos.
Cardamonin has been used as a standard in high performance liquid chromatography (HPLC) to analyze phenolic compounds in acacia honey samples.

生物化学的/生理学的作用

Wnt/β-カテニンシグナリングは、小眼球症関連転写因子(MITF)やチロシナーゼの発現に関係しています。カルダモニンは、アルピニア属(ショウガ科の植物種)由来のカルコンです。最近の知見で、この化合物がWnt/β-カテニンシグナリング経路を抑制することにより、メラニン細胞の色素沈着を阻害することが確認されています。カルダモニンは、プロテアソームを介したβ-カテニンの分解(GSK-3β非依存性経路)を伴ったメカニズムによりWnt/β-カテニンシグナリングを抑制します。よって、カルダモニンは、色素過剰沈着に対する化粧品や医学的治療に利用する美白剤として有望視されています。その他の研究では、NF-kBの核トランスロケーションやIk-Bαリン酸化の抑制を通じ、抗炎症作用を発揮することも示されています。

ピクトグラム

Exclamation mark

シグナルワード

Warning

危険有害性情報

危険有害性の分類

Acute Tox. 4 Oral

保管分類コード

11 - Combustible Solids

WGK

WGK 3

引火点(°F)

Not applicable

引火点(℃)

Not applicable


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