T7204

トレミフェン クエン酸塩

≥98% (HPLC)

• 別名: (Z)-2-(4-(4-クロロ-1,2-ジフェニル-1-ブテニル)フェノキシ)-N,N-ジメチルエタンアミン, Acapodene, Fareston, GTx 006, Z-トレミフェン
• 実験式（ヒル表記法）: C₂₆H₂₈ClNO · C₆H₈O₇
• CAS番号: 89778-27-8
• 分子量: 598.08
• NACRES: NA.77
• PubChem Substance ID: 329826860
• UNSPSC Code: 51111800
• MDL number: MFCD01729016
• Assay: ≥98% (HPLC)
• Form: powder
• Storage condition: desiccated

特性

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• storage condition: desiccated
• color: white to off-white
• solubility: DMSO: >10 mg/mL
• storage temp.: 2-8°C
• SMILES string: OC(=O)CC(O)(CC(O)=O)C(O)=O.CN(C)CCOc1ccc(cc1)C(=C(\CCCl)c2ccccc2)\c3ccccc3
• InChI: 1S/C26H28ClNO.C6H8O7/c1-28(2)19-20-29-24-15-13-23(14-16-24)26(22-11-7-4-8-12-22)25(17-18-27)21-9-5-3-6-10-21;7-3(8)1-6(13,5(11)12)2-4(9)10/h3-16H,17-20H2,1-2H3;13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)/b26-25-;
• InChI key: IWEQQRMGNVVKQW-OQKDUQJOSA-N
• Gene Information: human ... ESR1(2099), ESR2(2100)

詳細

General description

Toremifene is a triphenylethylene derivative. It exhibits antitumor and antiestrogen effects. Toremifene has estrogen-agonist effects on blood lipids and endometrium.

Application

Toremifene citrate salt has been used:

• in cell-based ELISA
• as a positive control to detect its antiviral activity against Ebola virus (EBOV)
• to treat MCF7 and T47D breast cancer cell lines

Biochem/physiol Actions

トレミフェンクエン酸塩は経口の選択的エストロゲンレセプターモジュレーター(SERM)です。トレミフェンクエン酸塩は進行性(転移性)乳癌に使用され、前立腺癌の予防についても評価が行われています。

Features and Benefits

This compound is featured on the Nuclear Receptors (Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Preparation Note

Toremifene citrate salt is soluble in DMSO at a concentration that is greater than 10 mg/ml.

安全性情報

• ピクトグラム: GHS05,GHS07,GHS09
• 注意喚起語: Danger
• ハザードコード: H302,H318,H410
• 注意事項: P264 - P273 - P280 - P301 + P312 - P305 + P351 + P338 - P391
• Hazard Classifications: Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1
• 保管分類: 11 - Combustible Solids
• 一体何が起きているの？: WGK 3
• 引火点 (F): Not applicable
• 引火点（°C）: Not applicable