ABCB1
ATP-binding cassette, sub-family B (MDR/TAP), member 1
Synonimy:
ABC20, CD243, CLCS, GP170, MDR1, P-GP, PGY1
Gatunek:
Human ABCB1 (5243), dog ABCB1 (403879), domestic cat ABCB1 (493707), Thale Cress ABCB1 (818265), naked mole-rat Abcb1 (101702843), domestic guinea pig Abcb1 (100733532), Domestic Rabbit ABCB1 (100008914), sheep ABCB1 (443367), Horse ABCB1 (100034074), cow ABCB1 (281585)
Identyfikator UniProtKB:
Identyfikator genu:
- Human(5243) Summary: The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. [provided by RefSeq, Jul 2008]
- dog(403879) ATP-binding cassette, sub-family B (MDR/TAP), member 1
- domestic cat(493707) ATP-binding cassette, sub-family B (MDR/TAP), member 1
- Thale Cress(818265) ABC transporter B family member 1
- naked mole-rat(101702843) ATP-binding cassette, sub-family B (MDR/TAP), member 1
- domestic guinea pig(100733532) ATP-binding cassette, sub-family B (MDR/TAP), member 1
- Domestic Rabbit(100008914) ATP-binding cassette, sub-family B (MDR/TAP), member 1
- sheep(443367) ATP-binding cassette, sub-family B (MDR/TAP), member 1
- Horse(100034074) ATP-binding cassette, sub-family B (MDR/TAP), member 1
- cow(281585) ATP-binding cassette, sub-family B (MDR/TAP), member 1
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Small Molecule - Agonist
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Small Molecule - Antagonist
Antibodies
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Zastosowanie
Anti-ABCB1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Reaktywność gatunkowa
human
Zastosowanie
immunofluorescence
immunohistochemistry
immunohistochemistry
Monoclonal Anti-P-Glycoprotein (MDR) antibody produced in mouse, clone F4, ascites fluid,
Reaktywność gatunkowa
hamster, human
Zastosowanie
ELISA
immunocytochemistry
immunohistochemistry
immunoprecipitation (IP)
radioimmunoassay
western blot
immunocytochemistry
immunohistochemistry
immunoprecipitation (IP)
radioimmunoassay
western blot
Anty-BCB1, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Reaktywność gatunkowa
human
Zastosowanie
immunofluorescence
Anti-MDR-1 Antibody, clone 1O12 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Reaktywność gatunkowa
human, mouse
Zastosowanie
affinity binding assay
flow cytometry
immunocytochemistry
immunohistochemistry
western blot
flow cytometry
immunocytochemistry
immunohistochemistry
western blot
Przeciwciało przeciw glikoproteinie P, klon 2U4E9, królicze monoklonalne, ,
Reaktywność gatunkowa
human, rat
Zastosowanie
immunohistochemistry
western blot
western blot
Cell Lines
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Kits
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Small Molecule - Mixed Agonist/Antagonist
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Dexamethasone, powder, γ-irradiated, BioXtra, suitable for cell culture, ≥80% (HPLC),
Gatunek
mouse, rat, human
Proteins
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SB-MDR1-Hi5-PREDEASY-ATPase kit, membrane based kit for Human MDR1 ATPase Transport Assays,
Gatunek
human
esiRNA
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