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Merck

ABCB1

ATP-binding cassette, sub-family B (MDR/TAP), member 1

Synonimy:
ABC20, CD243, CLCS, GP170, MDR1, P-GP, PGY1
Gatunek:
Human ABCB1 (5243), dog ABCB1 (403879), domestic cat ABCB1 (493707), Thale Cress ABCB1 (818265), naked mole-rat Abcb1 (101702843), domestic guinea pig Abcb1 (100733532), Domestic Rabbit ABCB1 (100008914), sheep ABCB1 (443367), Horse ABCB1 (100034074), cow ABCB1 (281585)
Identyfikator UniProtKB:
P08183, A8K294, Q12755, Q14812
Identyfikator genu:
  • Human(5243) Summary: The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. [provided by RefSeq, Jul 2008]
  • dog(403879) ATP-binding cassette, sub-family B (MDR/TAP), member 1
  • domestic cat(493707) ATP-binding cassette, sub-family B (MDR/TAP), member 1
  • Thale Cress(818265) ABC transporter B family member 1
  • naked mole-rat(101702843) ATP-binding cassette, sub-family B (MDR/TAP), member 1
  • domestic guinea pig(100733532) ATP-binding cassette, sub-family B (MDR/TAP), member 1
  • Domestic Rabbit(100008914) ATP-binding cassette, sub-family B (MDR/TAP), member 1
  • sheep(443367) ATP-binding cassette, sub-family B (MDR/TAP), member 1
  • Horse(100034074) ATP-binding cassette, sub-family B (MDR/TAP), member 1
  • cow(281585) ATP-binding cassette, sub-family B (MDR/TAP), member 1

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Small Molecule - Agonist

Numer produktu
Opis
Gatunek
150215
9(10H)-akrydanon, 99%,
Gatunek
human
H6909
Hydrocortisone solution, 50 μM, sterile-filtered, BioXtra, suitable for cell culture,
Gatunek
human, mouse, rat
H0135
Hydrocortisone, γ-irradiated, powder, BioXtra, suitable for cell culture,
Gatunek
human, mouse, rat
H3160
Hydrocortisone, meets USP testing specifications,
Gatunek
human, mouse, rat
H4001
Hydrocortisone, ≥98% (HPLC),
Gatunek
human, mouse, rat

Small Molecule - Antagonist

Numer produktu
Opis
Gatunek
142662
Chlorosulfonyl isocyanate, 98%,
Gatunek
human
I8898
Ivermectin, ,
Gatunek
mouse, human
O104
Omeprazole, solid,
Gatunek
human
C6019
Clotrimazole, ,
Gatunek
mouse, human
45674
Erythromycin, tested according to Ph. Eur.,
Gatunek
mouse, human

Antibodies

Numer produktu
Opis
Reaktywność gatunkowa
Zastosowanie
SAB2108868
Anti-ABCB1 antibody produced in rabbit FITC conjugated, affinity isolated antibody,
Reaktywność gatunkowa
bovine, canine, guinea pig, horse, human, mouse, pig, rabbit, sheep, zebrafish
Zastosowanie
immunohistochemistry
MAB4334
Anti-MDR1 Antibody, conformational extracellular epitope, clone UIC2, clone UIC2, Chemicon®, from mouse,
Reaktywność gatunkowa
human, primate
Zastosowanie
flow cytometry
immunofluorescence
immunohistochemistry
immunoprecipitation (IP)
MAB4120
Przeciwciało anty-MDR1, klon JSB-1, culture supernatant, clone JSB-1, Chemicon®,
Reaktywność gatunkowa
hamster, human
Zastosowanie
flow cytometry
immunocytochemistry
immunohistochemistry
western blot
MAB4334Z
Anti-MDR1 Antibody, clone UIC2, azide free, clone UIC2, Chemicon®, from mouse,
Reaktywność gatunkowa
human, primate
Zastosowanie
flow cytometry
immunofluorescence
immunohistochemistry
immunoprecipitation (IP)
HPA002199
Anti-ABCB1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Reaktywność gatunkowa
human
Zastosowanie
immunofluorescence
immunohistochemistry

Cell Lines

Numer produktu
Opis
Gatunek
MTOX1303
Canine MDR1 Knockout, Human MDR1 Knockin MDCKII Cells, ,
Gatunek
human
MTOX1019
Komórki HepaRG™ z nokautem MDR1, 1 vial,
Gatunek
human
MTOX1071
Kidney PTEC MDR1 KnockoutCells [MDR1 knock out (-/-)], ,
Gatunek
human
MTOX1001
MDR1 Knockout Caco-2 Cells, one vial,
Gatunek
human
MTOX1012
Komórki CAR Knockout HepaRG™, 1 vial,
Gatunek

Kits

Numer produktu
Opis
Gatunek
MAK161
Multidrug Resistance Assay Kit, (Fluorometric MDR Assay),
Gatunek
human, mouse, rat

Small Molecule - Mixed Agonist/Antagonist

Numer produktu
Opis
Gatunek
D4902
Dexamethasone, powder, BioReagent, suitable for cell culture, ≥97%,
Gatunek
mouse, rat, human
D8893
Dexamethasone, powder, γ-irradiated, BioXtra, suitable for cell culture, ≥80% (HPLC),
Gatunek
mouse, rat, human
D9184
Dexamethasone, meets USP testing specifications,
Gatunek
mouse, rat, human
D1756
Dexamethasone, ≥98% (HPLC), powder,
Gatunek
mouse, rat, human
31375
Dexamethasone, tested according to Ph. Eur.,
Gatunek
mouse, rat, human

Proteins

Numer produktu
Opis
Gatunek
SBPE01
SB-MDR1-Hi5-PREDEASY-ATPase kit, membrane based kit for Human MDR1 ATPase Transport Assays,
Gatunek
human

esiRNA

Numer produktu
Opis
Gatunek
EHU131661
MISSION® esiRNA, targeting human ABCB1,
Gatunek
human