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Inhibition of angiogenesis by antioxidant micelles.

Inhibition of angiogenesis by antioxidant micelles.

Advanced healthcare materials (2014-09-13)

Masaki Moriyama, Stéphanie Metzger, André J van der Vlies, Hiroshi Uyama, Martin Ehrbar, Urara Hasegawa

ABSTRAKT

Antioxidant micelles capable of scavenging reactive oxygen species (ROS) are prepared from poly(ethylene glycol)-b-poly(dopamine) block copolymers. The micelles inhibit tube formation of human umbilical vein endothelial cells (HUVECs) by scavenging endogenous ROS. Furthermore, the micelles inhibit angiogenesis in the chicken ex ovo chorioallantoic membrane assay. The results show that antioxidant micelles containing catechol moieties may be useful in anti-angiogenic therapy to treat various diseases such as cancer.

MATERIAŁY

Numer produktu

Marka

Opis produktu

Sigma-Aldrich

Sodium chloride solution, 0.85%

Supelco

Dopamine hydrochloride, Pharmaceutical Secondary Standard; Certified Reference Material

SAFC

Sodium chloride solution, 5 M

Lysine hydrochloride, European Pharmacopoeia (EP) Reference Standard

Supelco

Triethylamine, analytical standard

Supelco

Dimethylformamide, Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

Hydrogen peroxide solution, 30 % (w/w), for ultratrace analysis

Supelco

Hydrogen chloride – methanol solution, ~1.25 m HCl (T), derivatization grade (GC derivatization), LiChropur^™

Millipore

Hydrogen peroxide solution, 3%, suitable for microbiology

Supelco

Hydrogen chloride – 2-propanol solution, ~1.25 M HCl (T), derivatization grade (GC derivatization), LiChropur^™

Sigma-Aldrich

Hydrochloric acid solution, ~6 M in H₂O, for amino acid analysis

Sigma-Aldrich

Triethylamine, puriss. p.a., ≥99.5% (GC)

Sigma-Aldrich

Hydrogen peroxide solution, tested according to Ph. Eur.

Sigma-Aldrich

Calcein-AM, suitable for fluorescence, BioReagent, ≥90% (HPLC)

Sigma-Aldrich

Sodium chloride, 99.999% trace metals basis

Sigma-Aldrich

Acryloyl chloride, 97.0%, contains <210 ppm MEHQ as stabilizer

Sigma-Aldrich

Glycine tert-butyl ester hydrochloride, 97%

Sigma-Aldrich

Triethylamine, ≥99.5%

Sigma-Aldrich

Sodium chloride, random crystals, 99.9% trace metals basis

Sigma-Aldrich

Acryloyl chloride, ≥97%, contains ~400 ppm phenothiazine as stabilizer

Sigma-Aldrich

Sodium chloride-³⁵Cl, 99 atom % ³⁵Cl

Sigma-Aldrich

Sodium hydrogen sulfate

Sigma-Aldrich

Ninhydrin, ACS reagent

Sigma-Aldrich

Diethyl ether

Sigma-Aldrich

Poly(dimethylsiloxane), viscosity 1.0 cSt (25 °C)

Sigma-Aldrich

Hexamethyldisiloxane, viscosity 0.65 cSt (25 °C)

Supelco

1,4-Dioxane, analytical standard

Supelco

1-Methyl-2-pyrrolidinone, analytical standard

Sigma-Aldrich

Sodium sulfate, BioUltra, anhydrous, ≥99.0% (T)

Sigma-Aldrich

Potassium bicarbonate, BioUltra, ≥99.5% (T)