A4599

L-Arginine monohydrochloride

• Synonym(s): (S)-(+)-2-Amino-5-[(aminoiminomethyl)amino]pentanoic acid monohydrochloride, (S)-(+)-Arginine hydrochloride
• Empirical Formula (Hill Notation): C₆H₁₄N₄O₂ · HCl
• CAS Number: 1119-34-2
• Molecular Weight: 210.66
• EC Number: 214-275-1
• UNSPSC Code: 12352209
• NACRES: NA.26
• Beilstein/REAXYS Number: 3631658
• MDL number: MFCD00064550

Properties

• biological source: non-animal source
• Quality Segment: 400
• assay: ≥98.5%
• form: crystalline powder
• technique(s): cell culture | mammalian: suitable
• impurities: endotoxin, heavy metals, residual solvents, tested
• solubility: H₂O: 100 mg/mL
• density: 1.42 g/cm³ at 20 °C
• anion traces: chloride (Cl^-): 16.58-17.00%, sulfate (SO₄^2-): ≤0.020%
• cation traces: As: ≤1.0 ppm, NH₄⁺: ≤0.02%, heavy metals: ≤10 ppm
• application(s): downstream processes; pharma/biopharma processes; pharmaceutical (small molecule)
• foreign activity: cytotoxicity, tested
• SMILES string: Cl[H].N[C@@H](CCCNC(N)=N)C(O)=O
• InChI: 1S/C6H14N4O2.ClH/c7-4(5(11)12)2-1-3-10-6(8)9;/h4H,1-3,7H2,(H,11,12)(H4,8,9,10);1H/t4-;/m0./s1
• InChI key: KWTQSFXGGICVPE-WCCKRBBISA-N

Description

General description

Our SAFC^® portfolio of high-quality raw materials for use in biopharmaceutical processing withstands strict quality control procedures plus the documentation and expertise to help our customers meet requirements as defined by the M-Clarity Program.

M-Clarity Program

Our comprehensive portfolio of upstream process chemicals not only provides biopharmaceutical manufacturers with high-quality raw materials for production of classical and novel therapies, but also helps them get to market faster and simplify regulatory challenges. Trust us to deliver supply chain transparency and reliable sourcing around the globe, streamlining your product qualification with best-in-class regulatory support and service.

To request documentation for this product, please contact Customer Support and select ‘Product Documentation′. Please note that access to the documentation for this product requires a confidentiality disclosure agreement.

Application

L-Arginine is a non-essential amino acid. It is used as a cell culture media component for the commercial biomanufacture of therapeutic recombinant proteins and monoclonal antibodies. L-Arginine monohydrochloride is a modified version of L-Arginine with improved solubility.

Biochem/physiol Actions

Substrate of nitric oxide synthase, which is converted to citrulline and nitric oxide (NO). Induces insulin release by a nitric oxide-dependent mechanism.

Legal Information

SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class: 11 - Combustible Solids
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• PPE (personal protective equipment): dust mask type N95 (US), Eyeshields, Gloves