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Bridged androstenediol analogs as ER-beta selective SERMs.

Bioorganic & medicinal chemistry letters (2007-04-24)
Timothy A Blizzard, Candido Gude, Wanda Chan, Elizabeth T Birzin, Marina Mojena, Consuelo Tudela, Fang Chen, Kristin Knecht, Qin Su, Bryan Kraker, Mark A Holmes, Susan P Rohrer, Milton L Hammond
ABSTRACT

A series of bridged androstenediol derivatives was prepared. The bridged compounds exhibited reduced ER-beta selectivity relative to uncyclized analogs.

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