Single hepatocellular carcinoma smaller than 2 cm: are ethanol injection and radiofrequency ablation equally effective?

Single hepatocellular carcinoma smaller than 2 cm: are ethanol injection and radiofrequency ablation equally effective?

Anticancer research (2015-01-01)

Maurizio Pompili, Nicoletta De Matthaeis, Antonio Saviano, Ilario De Sio, Giampiero Francica, Franco Brunello, Alessandro Cantamessa, Antonio Giorgio, Umberto Scognamiglio, Fabio Fornari, Francesco Giangregorio, Fabio Piscaglia, Silvia Gualandi, Eugenio Caturelli, Paola Roselli, Laura Riccardi, Gian Ludovico Rapaccini

PMID25550567

ABSTRACT

The impact of radiofrequency ablation (RFA) and percutaneous ethanol injection (PEI) on survival in patients with small hepatocellular carcinoma (HCC) is unclear. We compared their efficacy in cirrhotics with single HCC ≤2 cm. Two hundred forty-four cirrhotics with single HCC ≤2 cm treated with PEI (108 cases) or RFA (136 cases) were enrolled in the study. Eighty-one patients in each group were selected for propensity score matching analysis. The five-year survival was not significantly different (64.7% in PEI and 72.9% in RFA group) but the 5-year recurrence (73.3% in PEI and 49% in RFA group, p=0.023) and local tumor progression (49% in PEI and 30.1% in RFA group, p=0.018) were higher in the PEI group. PEI and RFA are equally effective in treating HCCs smaller than 2 cm in terms of 5-year survival, despite higher cumulative and local recurrence rates, in patients treated with PEI.

MATERIALS

Product Number

Brand

Product Description

E-035

Supelco

Ethanol-25, 25 mg/dL in H₂O, ampule of 10 × 1.2 mL, certified reference material, Cerilliant^®

E-036

Supelco

Ethanol-400 (10 ampules/kit), 400 mg/dL in H₂O, ampule of 10 × 1.2 mL, certified reference material, Cerilliant^®

E-053

Supelco

Ethanol-500, 500 mg/dL in H₂O, ampule of 10 × 1.2 mL, certified reference material, Cerilliant^®

E-056

Supelco

Ethanol-20 (10 ampules/kit), 20 mg/dL in H₂O, ampule of 10 × 1.2 mL, certified reference material, Cerilliant^®

48075

Supelco

Ethanol solution, certified reference material, 2000 μg/mL in methanol

2858

Sigma-Aldrich

Ethanol Fixative 80% v/v, suitable for fixing solution (blood films)

E2385

Supelco

Ethanol standards 10% (v/v), 10 % (v/v) in H₂O, analytical standard

676829

Sigma-Aldrich

Reagent Alcohol, anhydrous, ≤0.005% water

362808

Sigma-Aldrich

Reagent Alcohol, reagent grade

277649

Sigma-Aldrich

Reagent Alcohol, anhydrous, ≤0.003% water

E7148

Sigma-Aldrich

Ethyl alcohol, Pure 190 proof, for molecular biology

PHR1070

Supelco

Dehydrated Alcohol, Pharmaceutical Secondary Standard; Certified Reference Material

1012772

USP

Dehydrated Alcohol, United States Pharmacopeia (USP) Reference Standard

09-0790

Sigma-Aldrich

Ethanol, JIS special grade, 94.8-95.8%

09-0800

Sigma-Aldrich

Ethanol, 94.8-95.8%

E-034

Supelco

Ethanol Calibration Kit, ampule of 10 × 1.2 mL, certified reference material, Cerilliant^®

270741

Sigma-Aldrich

Reagent Alcohol, denatured, suitable for HPLC

187380

Sigma-Aldrich

Ethyl alcohol, denatured, denatured, reagent grade

E-041

Supelco

Ethanol-150, 150 mg/dL in H₂O, ampule of 10 × 1.2 mL, certified reference material, Cerilliant^®

E-045

Supelco

Ethanol-40, 40 mg/dL in H₂O, ampule of 10 × 1.2 mL, certified reference material, Cerilliant^®

493546

Sigma-Aldrich

Ethyl alcohol, Pure, 200 proof, meets USP testing specifications

459828

Sigma-Aldrich

Ethyl alcohol, Pure, 200 proof

E7023

Sigma-Aldrich

Ethyl alcohol, Pure 200 proof, Molecular Biology

459844

Sigma-Aldrich

Ethyl alcohol, Pure, 200 proof, ACS reagent, ≥99.5%

32221

Sigma-Aldrich

Ethanol, puriss. p.a., absolute, ≥99.8% (GC)

09-0760

Sigma-Aldrich

Ethanol, ≥99.5%, SAJ super special grade

459836

Sigma-Aldrich

Ethyl alcohol, Pure, 200 proof, anhydrous, ≥99.5%

09-0852

Sigma-Aldrich

Ethanol, ≥99.5%

09-0830

Sigma-Aldrich

Ethanol, JIS 300, ≥99.5%, suitable for residue analysis

09-0832

Sigma-Aldrich

Ethanol, JIS 1000, ≥99.5%, suitable for residue analysis