Custom siRNA Libraries & Panels

MISSION^® Custom siRNA Libraries & Panels are the most compelling collections for high-throughput screening of therapeutic-value target genes. The flexible format facilitates research for scientists who are interested in specific classes of genes as well as those who need to generate information across the entire druggable genome.

Product Benefits

• Duplexes designed using the Rosetta Algorithm, one of the most powerful tools for high target specificity and efficient gene knockdown
• Up to 3 duplexes available per gene, thereby allowing for optional pooling
• Amounts of material provided allow for multiple screenings and hit follow-up
• Gene targets picked in collaboration with major pharmaceutical company

Product Features

• 21mer siRNA duplexes with dTdT overhangs
• Duplex amounts provided vary (see list below)
• 1 to 3 duplexes available per gene
• Duplexes formatted in multiple 96-well plates
  o   80 duplexes per plate
  o   First/last columns empty
  o   Dry
• Items provided electronically, include:
  o   Plate maps
  o   Target gene list
  o   Sequence information
• Controls may be available (inquire)

Available Libraries & Panels

Select the library or panel of interest and then use the button above to complete the quote request form. To learn if controls are included as well as the list of genes in the library or panel of interest, please send an email to [email protected].

Library / Panel No.	Product Name	Number of Targets	Duplex Amount
Human
1	MISSION® siRNA Human Druggable Genome Library	6655	1 nmol
2	MISSION® Human Gene Family Panels Ligase Panel	949	1 nmol
3	MISSION® siRNA Human Gene Family Panels Human Growth Factors/Receptors Panel	375	1 nmol
4	MISSION® siRNA Human Gene Family Panels Cell Adhesion and Cytoskeleton Panel	496	1 nmol
5	MISSION® siRNA Human Gene Family Panels Ion Channel and Transporters Panel	639	1 nmol
6	MISSION® siRNA Human Gene Family Panels Assorted Function Panel	228	1 nmol
7	MISSION® siRNA Human Gene Family Panels GPCR Panel	304	1 nmol
8	MISSION® siRNA Human Gene Family Panels Hydrolase Panel	204	1 nmol
9	MISSION® siRNA Human Gene Family Panels Metabolism and Cell Traffic Panel	217	1 nmol
10	MISSION® Human Nucleic Acid Binding Panel	310	1 nmol
11	MISSION® siRNA Human Gene Family Panels Oxidoreductase Panel	338	1 nmol
12	Human Gene Family Panels Protease Panel	379	1 nmol
13	MISSION® siRNA Human Gene Family Panels Cell Regulation Panel	227	1 nmol
14	MISSION® siRNA Human Gene Family Panels Transfer and Carrier Proteins Panel	71	1 nmol
15	MISSION® siRNA Human Gene Family Panels Transferase Panel	184	1 nmol
16	MISSION® siRNA Human Gene Family Set Kinase Panel	719	0.25 nmol
17	MISSION® siRNA Human Phosphatase Panel	303	0.25 nmol
Mouse
18	MISSION® siRNA Mouse Kinase Panel	623	0.5 nmol
Rat
19	MISSION® siRNA Rat Druggable Genome Library	6016	1 nmol
20	MISSION® siRNA Rat Gene Family Panels Ligase Panel	816	1 nmol
21	MISSION® siRNA Rat Gene Family Panels Kinase Panel	669	1 nmol
22	MISSION® siRNA Rat Gene Family Panels Phosphatase Panel	266	1 nmol
23	MISSION® siRNA Rat Gene Family Panels Growth Factors/Receptors Panel	342	1 nmol
24	MISSION® siRNA Rat Gene Family Panels Cell Adhesion and Cytoskeleton Panel	433	1 nmol
25	MISSION® siRNA Rat Gene Family Panels Ion Channel and Transporters Panel	594	1 nmol
26	MISSION® siRNA Rat Gene Family Panels Assorted Function Panel	210	1 nmol
27	MISSION® siRNA Rat Gene Family Panels GPCR Panel	275	1 nmol
28	MISSION® siRNA Rat Gene Family Panels Hydrolase Panel	188	1 nmol
29	MISSION® siRNA Rat Gene Family Panels Metabolism and Cell Traffic Panel	201	1 nmol
30	MISSION® siRNA Rat Gene Family Panels Nucleic Acid Binding Panel	287	1 nmol
31	MISSION® siRNA Rat Gene Family Panels Oxidoreductase Panel	302	1 nmol
32	MISSION® siRNA Rat Gene Family Panels Protease Panel	341	1 nmol
33	MISSION® siRNA Rat Gene Family Panels Cell Surface and Nuclear Receptors Panel	647	1 nmol
34	MISSION® siRNA Rat Gene Family Panels Cell Regulation Panel	214	1 nmol
35	MISSION® siRNA Rat Gene Family Panels Transfer and Carrier Proteins Panel	66	1 nmol
36	MISSION® siRNA Rat Gene Family Panels Transferase Panel	174	1 nmol

References

1. Hoorn EJ, Meima ME. 2012. Predicting kinase-substrate interactions in the era of proteomics. Focus on "Identifying protein kinase target preferences using mass spectrometry". American Journal of Physiology-Cell Physiology. 303(7):C711-C712. https://doi.org/10.1152/ajpcell.00232.2012

2. Meng W, Mushika Y, Ichii T, Takeichi M. 2008. Anchorage of Microtubule Minus Ends to Adherens Junctions Regulates Epithelial Cell-Cell Contacts. Cell. 135(5):948-959. https://doi.org/10.1016/j.cell.2008.09.040

3. Matsubara T, Kida K, Yamaguchi A, Hata K, Ichida F, Meguro H, Aburatani H, Nishimura R, Yoneda T. 2008. BMP2 Regulates Osterix through Msx2 and Runx2 during Osteoblast Differentiation. Journal of Biological Chemistry. 283(43):29119-29125. https://doi.org/10.1074/jbc.m801774200

4. 2015. Host Factors in Retroviral Integration and the Selection of Integration Target Sites.1035-1050. https://doi.org/10.1128/microbiolspec.mdna3-0026-2014

5. Zhang XD. 2008. Genome-wide screens for effective siRNAs through assessing the size of siRNA effects. BMC Research Notes. 1(1):33. https://doi.org/10.1186/1756-0500-1-33

6. Linsley PS, Jackson AL. 2010. Hidden reach of the micromanagers. BMC Biol. 8(1): https://doi.org/10.1186/1741-7007-8-53

7. Majercak J, Ray WJ, Espeseth A, Simon A, Shi X, Wolffe C, Getty K, Marine S, Stec E, Ferrer M, et al. 2006. LRRTM3 promotes processing of amyloid-precursor protein by BACE1 and is a positional candidate gene for late-onset Alzheimer's disease. Proceedings of the National Academy of Sciences. 103(47):17967-17972. https://doi.org/10.1073/pnas.0605461103