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Merck

PHR1140

酮咯酸氨丁三醇

Pharmaceutical Secondary Standard; Certified Reference Material

别名:

酮咯酸 三羟甲基氨基甲烷盐, 托拉多尔, (±)-5-苄基-2,3-二氢-1H-吡咯嗪-1羧酸 三羟甲基氨基甲烷盐

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500 MG

$189.00

$189.00


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关于此项目

经验公式(希尔记法):
C15H13NO3 · C4H11NO3
化学文摘社编号:
分子量:
376.40
NACRES:
NA.24
PubChem Substance ID:
UNSPSC Code:
41116107
MDL number:

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产品名称

酮咯酸氨丁三醇, Pharmaceutical Secondary Standard; Certified Reference Material

InChI

1S/C15H13NO3.C4H11NO3/c17-14(10-4-2-1-3-5-10)13-7-6-12-11(15(18)19)8-9-16(12)13;5-4(1-6,2-7)3-8/h1-7,11H,8-9H2,(H,18,19);6-8H,1-3,5H2

SMILES string

NC(CO)(CO)CO.OC(=O)C1CCn2c1ccc2C(=O)c3ccccc3

InChI key

BWHLPLXXIDYSNW-UHFFFAOYSA-N

grade

certified reference material
pharmaceutical secondary standard

agency

traceable to Ph. Eur. Y0000486
traceable to USP 1356665

API family

ketorolac

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

Quality Level

Gene Information

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1356665Y0000626Y0000486
technique(s)

HPLC: suitable, gas chromatography (GC): suitable

technique(s)

-

technique(s)

-

technique(s)

-

format

neat

format

neat

format

neat

format

neat

Quality Level

300

Quality Level

-

Quality Level

-

Quality Level

-

grade

certified reference material, pharmaceutical secondary standard

grade

pharmaceutical primary standard

grade

pharmaceutical primary standard

grade

pharmaceutical primary standard

storage temp.

2-30°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

agency

traceable to Ph. Eur. Y0000486

agency

-

agency

-

agency

-

Application

这些二级标准品是合格的认证标准物质(CRM)。它们适用于多种分析应用,包括但不限于药物释放测试、药物的定性和定量分析方法开发、食品和饮料质量控制检测以及其他校准需求。
酮咯酸氨丁三醇可作为药物参考标准品,通过反相高效液相色谱[1]和分光光度法技术对药物制剂[1][2]中的分析物进行定量。[2]

General description

用于质量控制的制药二级标准品,为制药实验室和制造商制备内部工作标准品提供了一种方便、高性价比的替代方案。酮咯酸氨丁三醇属于非甾体类抗炎药,其作用方式涉及到抑制前列腺素的合成。它具有抗炎、解热、镇痛作用。[1]

Other Notes

分析物的数值在批次间变化很大。
在我们的NMR在线平台ChemisTwin®上可以找到本品对应的数字化标准物质。您可使用ChemisTwin®上的数字等效品鉴定您的样品并进行定量分析(使用数字化外标)。可查看该物质的NMR谱图,只需点击几次鼠标,就能进行在线样品比对。欢迎点击了解更多,开启免费试用之旅。
要查看该材料的分析证书示例,请在下方栏位输入 LRAA7191。这只是一个示例证书,可能不是您收到的批次。
该认证参考物质(CRM)根据 ISO 17034ISO/IEC 17025进行生产和认证。所有关于客户关系管理的信息都可以在分析证书上找到。

Analysis Note

These secondary standards offer multi-traceability to the USP and EP (PhEur) primary standards, where they are available.

pictograms

Skull and crossbones

signalword

Danger

Hazard Classifications

Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


分析证书(COA)

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A validated RP-HPLC method for simultaneous estimation of febuxostat and ketorolac tromethamine in pharmaceutical formulations
Gandla K, et al.
Journal of Drug Delivery and Therapeutics, 2(3) (2012)
Simultanious spectrophotometric estimation of ofloxacin and ketorolac tromethamine in ophthalmic dosage form
Fegade DJ, et al.
International Journal of ChemTech Research, 1(3), 189-194 (2009)
V R Sinha et al.
Expert opinion on drug delivery, 6(9), 961-975 (2009-08-12)
Ketorolac tromethamine (KT) is a non-steroidal anti-inflammatory drug that belongs to the class of heteroaryl acetic acid derivatives. It is a non-selective cyclooxygenase (COX) inhibitor, being marketed in the racemate form. Most of its analgesic and COX inhibitory activity is
Gwen M Grimsby et al.
Mayo Clinic proceedings, 87(11), 1089-1097 (2012-10-13)
To evaluate the efficacy and safety of a novel, continuous intravenous infusion of ketorolac, a powerful nonopioid analgesic, for postoperative pain control. A prospective, double-blind, randomized, placebo-controlled trial of a continuous infusion of ketorolac tromethamine in 1 L of normal
Aida Kulo et al.
European journal of drug metabolism and pharmacokinetics, 38(1), 1-4 (2012-11-28)
Compared to female volunteers or postpartum, ketorolac clearance is higher at delivery. To explore the alterations that explain this higher clearance, urinary ketorolac metabolites collected at delivery (n = 40) were compared to female volunteers (unpaired, n = 8) or postpartum (paired, n = 8) following

Questions

1–2 of 2 Questions  
  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf

      Helpful?

  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

      Helpful?

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