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Merck

F4503

Sigma-Aldrich

铁蛋白 来源于马脾脏

Type I, saline solution

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$145.00
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$470.00
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$808.00

$145.00

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关于此项目

化学文摘社编号:
9007-73-2
MDL號碼:
MFCD00081593
分類程式碼代碼:
12352202
NACRES:
NA.77

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無菌

sterile-filtered

品質等級

300

種類

Type I

形狀

saline solution

分子量

H subunit ~21 kDa
L subunit ~19 kDa

顏色

red to brown

正離子痕跡

Cd: ≤1% (as % of ferritin)

儲存溫度

2-8°C

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此商品
F7879F6754F6879
铁蛋白 来源于马脾脏 Type I, saline solution

Sigma-Aldrich

F4503

铁蛋白 来源于马脾脏

阳离子铁蛋白 来源于马脾脏 10 mg/mL in 0.15 M NaCl

Sigma-Aldrich

F7879

阳离子铁蛋白 来源于马脾脏

铁蛋白 来源于人类肝脏 Type IV, 10 μg/mL

Sigma-Aldrich

F6754

铁蛋白 来源于人类肝脏

铁蛋白 来源于人类脾脏 Type V, 10 μg/mL in 0.15 M NaCl, 10 mM Tris, pH 8.0, containing 0.1% sodium azide

Sigma-Aldrich

F6879

铁蛋白 来源于人类脾脏

mol wt

H subunit ~21 kDa, L subunit ~19 kDa

mol wt

-

mol wt

H subunit ~21 kDa, L subunit ~19 kDa, ~440 kDa (a shell of 24 protein subunits (apoferritin) and a core of Fe3+ ions)

mol wt

-

form

saline solution

form

liquid

form

liquid

form

liquid

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

Quality Level

300

Quality Level

200

Quality Level

100

Quality Level

100

sterility

sterile-filtered

sterility

sterile-filtered

sterility

0.2 μm filtered

sterility

sterile-filtered

type

Type I

type

-

type

Type IV

type

Type V

一般說明

壳蛋白 24 个蛋白质亚基（脱铁铁蛋白）和核心 Fe 3+ 离子，肽 MW 为 440 kDa。回顾铁蛋白样铁储存蛋白超家族，在地球上的生命中几乎无处不在。

應用

来自马脾的铁蛋白已用于：
  • 分枝杆菌生长测定[1]
  • 尺寸排阻色谱[2][3]
  • 标记巨噬细胞[4]
  • 作为 μ 介子自旋光谱学的参考标准[5]

生化／生理作用

广泛的储铁蛋白在铁代谢中起关键作用。其用作细胞内的铁储备（特别是在脾脏、肝脏、肠粘膜和骨髓中）并参与铁解毒。
广泛的储铁蛋白在铁代谢中起关键作用。其用作细胞内的铁储备（特别是在脾脏、肝脏、肠粘膜和骨髓中）并参与铁解毒。 研究表明，铁蛋白铁的掺入是由与铁蛋白 H 亚基相关的铁氧化酶活性和与铁蛋白 L 亚基相关的成核中心介导的。 从铁蛋白释放铁在铁依赖性脂质过氧化中具有重要作用，并且可能在体内促成自由基诱导的细胞损伤。因此，通过结合铁，铁蛋白可以起抗氧化剂的作用。

儲存類別代碼

12 - Non Combustible Liquids

水污染物質分類（WGK）

WGK 2

閃點（°F）

Not applicable

閃點（°C）

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000501826
0000501826
0000501197
0000501197
0000486173

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Brian O'Callahan et al.
Langmuir : the ACS journal of surfaces and colloids, 37(41), 12089-12097 (2021-10-06)
The COVID-19 pandemic has claimed millions of lives worldwide, sickened many more, and has resulted in severe socioeconomic consequences. As society returns to normal, understanding the spread and persistence of SARS CoV-2 on commonplace surfaces can help to mitigate future
Human-brain ferritin studied by muon spin rotation: a pilot study
Bossoni L, et al.
Journal of Physics. Condensed Matter : An Institute of Physics Journal, 29(41), 415801-415801 (2017)
Defining the Architecture of the Core Machinery for the Assembly of Fe-S Clusters in Human Mitochondria
Methods in Enzymology, 595, 107-160 (2017)
Yves Gossuin et al.
Magnetic resonance in medicine, 48(6), 959-964 (2002-12-05)
Ferritin, the iron-storing protein, speeds up proton transverse magnetic relaxation in aqueous solutions. This T(2) shortening is used in MRI to quantify iron in the brain and liver. Current theoretical models underestimate the relaxation enhancement by ferritin at imaging fields
Adipocyte model of Mycobacterium tuberculosis infection reveals differential iron availability to bacilli in the lipid rich caseous environment
Nandy A, et al.
Infection and Immunity, IAI-00041 (2018)
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Questions

1–8 of 8 Questions  

  1. Hi, I've just purchased a Ferritin from equine spleen (liquid, 100mg, cas No:9007-73-2, MDL No: MFCD00081593), however, I didn't find how many mL this solution is on the product label. Can you please provide any information regarding volume? Thanks.

    1 answer

    1. The concentration, and thus the volume, of the Ferritin will vary for individual lots. The concentration can be found on the lot specific Certificate of Analysis, which can be retrieved by entering the lot number here:
      https://www.sigmaaldrich.com/product/sigma/f4503#product-documentation

      The volume can be determined using the following formula:
      Units provided / Units per mL = mL provided

      The concentration of the Ferritin is currently specified to be ≤125mg/ml
      https://www.sigmaaldrich.com/specification-sheets/115/477/F4503-BULK________SIGMA____.pdf

      Helpful?

  2. Does it run as a 44kDa specie or 21kDa+19kDa in size exclusion chromatography?

    1 answer

    1. This product is not analyzed by chromatography. However, historical data indicates the material runs primarily at 20-22kD and 13-15kD in SDS electrophoresis studies. Additional bands appear at the 3000 - 5000 molecular weight range.

      Helpful?

  3. What is the concentration of salt(s) in the saline solution carrying the protein?

    1 answer

    1. The saline solution is a 0.15 M sodium chloride solution. The concentration of 0.15 M can also be written as 8.8 mg NaCl per mL, or the textbook "0.9%" for normal saline.

      Helpful?

  4. Hi, I was wondering if I could get the volume of ferritin present in each of the package sizes? Thank you

    1 answer

    1. The concentration of this product is lot specific and will impact the final volume received. Typical lots range from 50 - 75 mg/mL. Please see the link below to review the product specification sheet:
      https://www.sigmaaldrich.com/specification-sheets/115/477/F4503-BULK________SIGMA____.pdf

      See below for potential volume ranges for each package size:
      F4503-25MG (0.5 - 0.33 mL)
      F4503-100MG (2 - 1.33 mL)
      F4503-500MG (10 - 6.66 mL)
      F4503-1G (20 - 13.33 mL)

      Helpful?

  5. Where is iron located in the ferritin molecule of Product F4503, Ferritin from equine spleen?

    1 answer

    1. Iron is located in the core of the ferritin molecule consisting of 24 subunits. Up to 4500 iron ions can be contained in this core.

      Helpful?

  6. Has Product F4503, Ferritin from equine spleen, been cell culture tested?

    1 answer

    1. The solution is sterile-filtered but has not been tested in cell culture.

      Helpful?

  7. What is the concentration of ferritin in solutions of Product F4503, Ferritin from equine spleen?

    1 answer

    1. The concentration of ferritin is lot specific and can be found on the Certificate of Analysis (CofA) for the specific lot.

      Helpful?

  8. What is the Department of Transportation shipping information for this product?

    1 answer

    1. Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.

      Helpful?

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