05-780

Anti-Akt3/PKBγ Antibody, clone GMA104

Name: Anti-Akt3/PKBγ Antibody, clone GMA104
Brand: MM

clone GMA104, Upstate^®, from mouse

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分類程式碼代碼:

12352203

eCl@ss:

32160702

NACRES:

NA.41

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生物源

mouse

品質等級

100

共軛

unconjugated

抗體表格

purified antibody

抗體產品種類

primary antibodies

無性繁殖

GMA104, monoclonal

物種活性

human

製造商／商標名

Upstate^®

技術

immunoprecipitation (IP): suitable
western blot: suitable

同型

IgG2a

NCBI登錄號

NM_005465

UniProt登錄號

Q9Y243

運輸包裝

wet ice

目標翻譯後修改

unmodified

基因資訊

human ... AKT3(10000)

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本產品	07-383	05-796	04-1643
Sigma-Aldrich 05-780 Anti-Akt3/PKBγ Antibody, clone GMA104	Sigma-Aldrich 07-383 Anti-Akt3/PKBγ Antibody	Sigma-Aldrich 05-796 Anti-Akt1/PKBα Antibody, clone AW24, rabbit monoclonal	Sigma-Aldrich 04-1643 Rabbit Anti-Mouse IgG Antibody, clone RM104
species reactivity human	species reactivity human	species reactivity human, mouse, rat	species reactivity mouse
antibody form purified antibody	antibody form affinity purified immunoglobulin	antibody form purified antibody	antibody form purified antibody
clone GMA104, monoclonal	clone polyclonal	clone AW24, monoclonal	clone RM104, monoclonal
biological source mouse	biological source rabbit	biological source rabbit	biological source rabbit
shipped in wet ice	shipped in dry ice	shipped in dry ice	shipped in wet ice
technique(s) immunoprecipitation (IP): suitable, western blot: suitable	technique(s) immunoprecipitation (IP): suitable, western blot: suitable	technique(s) immunoprecipitation (IP): suitable, western blot: suitable	technique(s) ELISA: suitable, western blot: suitable

一般說明

~60kDa

免疫原

peptide corresponding to amino acids 119-131 (CSPTSQIDNIGEE) of human Akt3/PKBγ

應用

Research Category
Signaling

Research Sub Category
PI3K, Akt, & mTOR Signaling

This Anti-Akt3/PKBγ Antibody, clone GMA104 is validated for use in IP, WB for the detection of Akt3/PKBγ.

生化／生理作用

Predicted to cross-react with mouse and rat based on sequence homology.

RhoA

外觀

Protein A purified

Buffered solution containing 0.1M Tris-Glycine, 0.15M NaCl, 0.05% Sodium Azide, pH 7.4.

Format: Purified

準備報告

Stable for 1 year at 2-8°C from date of receipt.

分析報告

routinely evaluated by immunoblot on RIPA lysates from Jurkat or HL-60 cells

法律資訊

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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儲存類別代碼

10 - Combustible liquids

水污染物質分類（WGK）

WGK 1

分析證明 (COA)

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K-Ras(V12) differentially affects the three Akt isoforms in lung and pancreatic carcinoma cells and upregulates E-cadherin and NCAM via Akt3.

Rebekka Geißert et al.

Cell communication and signaling : CCS, 22(1), 85-85 (2024-01-31)

K-Ras is the most frequently mutated Ras variant in pancreatic, colon and non-small cell lung adenocarcinoma. Activating mutations in K-Ras result in increased amounts of active Ras-GTP and subsequently a hyperactivation of effector proteins and downstream signaling pathways. Here, we

Characterization of PDK2 activity against protein kinase B gamma.

Conrad P Hodgkinson et al.

Biochemistry, 41(32), 10351-10359 (2002-08-07)

Protein kinase B (PKB), also known as Akt, is a serine/threonine protein kinase controlled by insulin, various growth factors, and phosphatidylinositol 3-kinase. Full activation of the PKB enzyme requires phosphorylation of a threonine in the activation loop and a serine

MicroRNA-497 impairs the growth of chemoresistant neuroblastoma cells by targeting cell cycle, survival and vascular permeability genes.

Aroa Soriano et al.

Oncotarget, 7(8), 9271-9287 (2016-01-30)

Despite multimodal therapies, a high percentage of high-risk neuroblastoma (NB) become refractory to current treatments, most of which interfere with cell cycle and DNA synthesis or function, activating the DNA damage response (DDR). In cancer, this process is frequently altered

The Akt isoforms are present at distinct subcellular locations.

Santi, SA; Lee, H

American Journal of Physiology. Cell Physiology null

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