B5016

苄普地尔盐酸盐

Name: 苄普地尔 盐酸盐
Brand: SIGMA

calcium channel blocker, powder

同義詞:

1-异丁氧基-2-吡咯烷基-3-（N-苄基苯胺）丙烷盐酸盐

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關於此項目

經驗公式（希爾表示法）:

C₂₄H₃₄N₂O · HCl

CAS 編號:

68099-86-5

分子量：:

403.00

MDL號碼:

MFCD00065498

分類程式碼代碼:

12352202

PubChem物質ID:

24277824

NACRES:

NA.77

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產品名稱

苄普地尔盐酸盐, powder

形狀

powder

品質等級

100

起源

Johnson & Johnson

SMILES 字串

Cl.CC(C)COCC(CN(Cc1ccccc1)c2ccccc2)N3CCCC3

InChI

1S/C24H34N2O.ClH/c1-21(2)19-27-20-24(25-15-9-10-16-25)18-26(23-13-7-4-8-14-23)17-22-11-5-3-6-12-22;/h3-8,11-14,21,24H,9-10,15-20H2,1-2H3;1H

InChI 密鑰

JXBBWYGMTNAYNM-UHFFFAOYSA-N

比較類似項目

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Show Differences

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本產品	P4670	SML1261	SML1882
Sigma-Aldrich B5016 苄普地尔盐酸盐	Sigma-Aldrich P4670 普罗帕酮盐酸盐	Sigma-Aldrich SML1261 Asimadoline hydrochloride	Sigma-Aldrich SML1882 RS 67333 hydrochloride
form powder	form powder	form powder	form powder
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level 100
originator Johnson & Johnson	originator Abbott	originator -	originator -
Gene Information human ... CACNA1A(773), CACNA1B(774), CACNA1C(775), CACNA1D(776), CACNA1E(777), CACNA1F(778), CACNA1G(8913), CACNA1H(8912), CACNA1I(8911), CACNA1S(779), CACNA2D1(781), CACNA2D2(9254), CACNA2D3(55799), CACNA2D4(93589), CACNB1(782), CACNB2(783), CACNB3(784), CACNB4(785), CACNG1(786), CACNG2(10369), CACNG3(10368), CACNG4(27092), CACNG5(27091), CACNG6(59285), CACNG7(59284), CACNG8(59283)	Gene Information human ... ABCB1(5243), ADRB1(153), ADRB2(154), ADRB3(155), CYP1A2(1544), SCN10A(6336), SCN11A(11280), SCN1A(6323), SCN2A(6326), SCN3A(6328), SCN4A(6329), SCN5A(6331), SCN7A(6332), SCN8A(6334), SCN9A(6335)	Gene Information -	Gene Information -

生化／生理作用

非选择性钙通道阻滞剂和 IV 类抗心律失常药；抑制Na⁺-Ca²⁺ 交换；体外抑制脑肿瘤细胞的生长。

特點和優勢

该化合物由 Johnson & Johnson 开发。如需浏览其他制药公司开发的化合物和批准的药物/候选药物列表，请点击此处。

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 2

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)

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分析證明 (COA)

Lot/Batch Number

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Clinical outcome in patients with paroxysmal or persistent atrial fibrillation receiving bepridil.

Tsuyoshi Shiga et al.

Circulation journal : official journal of the Japanese Circulation Society, 75(6), 1334-1342 (2011-04-13)

It is unknown whether bepridil improves cardiovascular events in atrial fibrillation (AF) patients, so this study evaluated the clinical outcome in paroxysmal or persistent AF patients receiving bepridil. We conducted a cohort study of 284 consecutive patients who received bepridil

Effects of Oral Calcium Dosage and Timing on Ethanol-Induced Sensitization of Locomotion in DBA/2 Mice.

Chikako Shimizu et al.

Biological & pharmaceutical bulletin, 41(7), 1049-1061 (2018-05-18)

Ethanol (EtOH) dosage, frequency, and paired associative learning affect the risk of alcoholism. Recently, Spanagel et al. reported that acamprosate calcium (Acam Ca) prescribed for alcoholism exerts an anti-relapse effect via Ca. Ca is contained in foods, sometimes consumed with

In vitro and experimental therapeutic studies of the calcium channel blocker bepridil: detection of viable Leishmania (L.) chagasi by real-time PCR.

Juliana Q Reimão et al.

Experimental parasitology, 128(2), 111-115 (2011-03-01)

The need for novel and efficacious drugs against neglected parasitic diseases, such as Leishmaniasis and American Trypanosomiasis, is certainly apparent. In this work, we evaluated the in vitro potential of the calcium channel blocker bepridil against Leishmania spp. and Trypanosoma

Bepridil facilitates early termination of spiral-wave reentry in two-dimensional cardiac muscle through an increase of intercellular electrical coupling.

Hiroki Takanari et al.

Journal of pharmacological sciences, 115(1), 15-26 (2010-12-16)

Bepridil is effective for conversion of atrial fibrillation to sinus rhythm and in the treatment of drug-refractory ventricular tachyarrhythmias. We investigated the effects of bepridil on electrophysiological properties and spiral-wave (SW) reentry in a 2-dimensional ventricular muscle layer of isolated

Bepridil and amiodarone simultaneously target the Alzheimer's disease beta- and gamma-secretase via distinct mechanisms.

Stefan Mitterreiter et al.

The Journal of neuroscience : the official journal of the Society for Neuroscience, 30(26), 8974-8983 (2010-07-02)

The two proteases beta-secretase and gamma-secretase generate the amyloid beta peptide and are drug targets for Alzheimer's disease. Here we tested the possibility of targeting the cellular environment of beta-secretase cleavage instead of the beta-secretase enzyme itself. beta-Secretase has an

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苄普地尔盐酸盐

calcium channel blocker, powder