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Merck

D2438

二甲基亚砜

sterile-filtered, BioPerformance Certified, meets EP, USP testing specifications, suitable for hybridoma

Dimethyl sulfoxide

同義詞:

DMSO, 甲基亚砜

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關於此項目

線性公式:
(CH3)2SO
CAS 編號:
分子量::
78.13
UNSPSC Code:
12191502
NACRES:
NA.75
PubChem Substance ID:
EC Number:
200-664-3
Beilstein/REAXYS Number:
506008
MDL number:
Grade:
BioPerformance Certified
Technique(s):
cell culture | hybridoma: suitable
cryopreservation: suitable
Bp:
189 °C (lit.)
Vapor pressure:
0.42 mmHg ( 20 °C)

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產品名稱

二甲基亚砜, sterile-filtered, BioPerformance Certified, meets EP, USP testing specifications, suitable for hybridoma

InChI key

IAZDPXIOMUYVGZ-UHFFFAOYSA-N

InChI

1S/C2H6OS/c1-4(2)3/h1-2H3

SMILES string

CS(C)=O

grade

BioPerformance Certified

agency

USP XXIV
meets EP testing specifications
meets USP testing specifications

vapor density

2.7 (vs air)

vapor pressure

0.42 mmHg ( 20 °C)

sterility

sterile-filtered

form

liquid

autoignition temp.

573 °F

expl. lim.

42 %, 63 °F

technique(s)

cell culture | hybridoma: suitable
cryopreservation: suitable

impurities

≤0.1% water

color

colorless

refractive index

n20/D 1.479 (lit.)

bp

189 °C (lit.)

mp

16-19 °C (lit.)

solubility

H2O: miscible (completely)

density

1.10 g/mL (lit.)

Quality Level

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1 of 4

本產品
4164041640-M34869
Quality Level

400

Quality Level

300

Quality Level

-

Quality Level

100

grade

BioPerformance Certified

grade

ACS reagent, puriss. p.a.

grade

ACS reagent, puriss. p.a.

grade

-

technique(s)

cell culture | hybridoma: suitable, cryopreservation: suitable

technique(s)

-

technique(s)

-

technique(s)

HPLC: suitable

solubility

H2O: miscible (completely)

solubility

-

solubility

-

solubility

-

form

liquid

form

liquid

form

liquid

form

liquid

vapor pressure

0.42 mmHg ( 20 °C)

vapor pressure

0.42 mmHg ( 20 °C)

vapor pressure

0.42 mmHg ( 20 °C)

vapor pressure

0.42 mmHg ( 20 °C)

Application

二甲基亚砜已被用在体内培养和诱导肝星状细胞(HSC)活化中的载体对照。[1][1]它还被用于制备储备溶液,以研究阿魏酸(FA)对髓核(NP)细胞的细胞毒性。[2]

Disclaimer

在室温下容易过冷并缓慢重融。 固化产品可以通过加热至室温来重新液化,而不会损害产品。

Features and Benefits

即用型无菌过滤产品,被方便地包装在隔垫螺帽琥珀色瓶中。 符合USP和EP检测的要求

General description

二甲基亚砜(DMSO)是一种非质子溶剂。不溶于水的治疗性和有毒分子通常溶于DMSO。液氮与诸如DMSO的冷冻保护剂结合使用是广泛使用的细胞保存方法。DMSO已用于制备多种分子的储备溶液,并同时也作为这些分子的对照。它已用于溶解迁移后细胞的细胞迁移试验。经BPC测试的DMSO也可满足生物技术和组织工程应用的要求。

存儲類別/等級

10 - Combustible liquids

wgk

WGK 1

flash_point_f

188.6 °F - closed cup

flash_point_c

87 °C - closed cup

ppe

Eyeshields, Gloves, type ABEK (EN14387) respirator filter


從最近期的版本中選擇一個:

分析證明 (COA)

Lot/Batch Number

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您可以在文件庫中找到最近購買的產品相關文件。

存取文件庫

A Oguro-Ando et al.
Molecular psychiatry, 20(9), 1069-1078 (2014-10-15)
Rare maternally inherited duplications at 15q11-13 are observed in ~1% of individuals with an autism spectrum disorder (ASD), making it among the most common causes of ASD. 15q11-13 comprises a complex region, and as this copy number variation encompasses many
Caroline Godfrey et al.
Human molecular genetics, 24(15), 4225-4237 (2015-05-03)
Splice modulation therapy has shown great clinical promise in Duchenne muscular dystrophy, resulting in the production of dystrophin protein. Despite this, the relationship between restoring dystrophin to established dystrophic muscle and its ability to induce clinically relevant changes in muscle
Claudia C Faria et al.
Cancer research, 75(1), 134-146 (2014-11-14)
Medulloblastoma is the most common malignant pediatric brain tumor, with metastases present at diagnosis conferring a poor prognosis. Mechanisms of dissemination are poorly understood and metastatic lesions are genetically divergent from the matched primary tumor. Effective and less toxic therapies
Mike Clements et al.
Toxicological sciences : an official journal of the Society of Toxicology, 140(2), 445-461 (2014-05-09)
Human stem cell derived cardiomyocytes (hESC-CM) provide a potential model for development of improved assays for pre-clinical predictive drug safety screening. We have used multi-electrode array (MEA) analysis of hESC-CM to generate multi-parameter data to profile drug impact on cardiomyocyte
Björn Zörner et al.
Brain : a journal of neurology, 137(Pt 6), 1716-1732 (2014-04-17)
Anatomical plasticity such as fibre growth and the formation of new connections in the cortex and spinal cord is one known mechanism mediating functional recovery after damage to the central nervous system. Little is known about anatomical plasticity in the

文章

以細胞系冷凍保存為目的的良好細胞庫實務概述。

Overview of good cell banking practices for cell line cryopreservation purposes.

Questions

1–10 of 16 Questions  
  1. For D2438-5X10ML, do they come in glass ampoule or bottle with lid?

    1 answer
    1. Yes, both package sizes have a septum cap closure as shown in the image below:

      Helpful?

  2. Hi, what is the difference between DMSO product# D2438 and D2650? What is Hybri-Max vs. BioPerformance certified and meets USP testing specification?

    1 answer
    1. Both D2438 and D2650 are suitable for cell culture. The D2650 is part of the Hybri-Max™ product line. Hybri-Max products have been tested for use in hybridoma creation and culture. The D2438 is part of the BioPerformance Certified group of products. These products are tested and optimized for use in biological applications. For this product and a number of others, this includes testing to meet USP and EP guidelines. Please see the links below to review a sample Certificate of Analysis for each item.
      D2650
      https://www.sigmaaldrich.com/product/sigma/d2438#product-documentation
      D2438
      https://www.sigmaaldrich.com/product/sigma/d2650#product-documentation

      Helpful?

  3. Purity grade of the product ?

    1 answer
    1. The purity of this product is listed on the lot specific Certificate of Analysis. Please navigate to the DOCUMENTATION section of the Product Detail Page to access a Certificate:
      https://www.sigmaaldrich.com/product/sigma/d2438#product-documentation

      Helpful?

  4. El DMSO es sensible a la luz, hay que tomar alguna precaución al respecto?

    1 answer
    1. This product is packaged in amber glass and is protected from light. The 10 mL size is packaged in a sealed ampule. Once opened, any content that is not used should also be stored in amber glass. For long term storage, the material may also be stored under inert gas to preserve the shelf life. Note that this material has a tendency to absorb water. Containers should be tightly sealed.

      Helpful?

  5. what are the storing conditions?

    1 answer
    1. This product is stored at room temperature. Store in a well-ventilated place. Keep cool. Please see the Material Safety Data Sheet for more information: https://www.sigmaaldrich.com/sds/sigma/d2438.

      Helpful?

  6. What is the difference between products D2438 and D8418?

    1 answer
    1. The D2438 is a BioPerformance Certified grade product suitable for cell culture, hybridoma creation, and cryopreservation. It is intended for research use only but does meet USP and EP testing requirements. The D8418 is a molecular biology-grade product suitable for DNA sequencing, PCR, and transfection. It has been tested for RNAse and DNAse. The products can be selected based on the application.

      Please view the sample Certificate of Analysis for each product to see the testing specifications associated with that item:
      https://www.sigmaaldrich.com/certificates/Graphics/COfAInfo/fluka/pdf/PDF734068.pdf
      https://www.sigmaaldrich.com/coa/SIGMA/D2438/RNBL8837

      Helpful?

  7. What is the basis for the endotoxin specification for Dimethyl sulfoxide (DMSO)?

    1 answer
    1. The industry standard for 'endotoxin free' is less than 1 EU/mL.

      Helpful?

  8. Dimethyl sulfoxide (DMSO) should be a liquid.  Why did it arrive as a solid?

    1 answer
    1. DMSO supercools easily, and re-melts slowly at room temperature. The melting point is 16-19 °C. The solidified product can be re-liquefied by warming to room temperature without detriment to the product.

      Helpful?

  9. What is the molarity of DMSO?

    1 answer
    1. DMSO will have a molarity of 14.1M, based on a density of 1.1 g/mL and a molecular weight of 78.13 g/mol.

      Helpful?

  10. Where does DMSO come from?

    1 answer
    1. DMSO is known to have been isolated from tree bark in the past. It is now a commericially synthesized solvent.

      Helpful?

1–10 of 16 Questions  

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