SML2566
CL097
≥98% (HPLC)
同義詞:
2-(Ethoxymethyl)-3H-imidazo[4,5-c]quinolin-4-amine, CL 097, CL-097
跳轉至
化驗
≥98% (HPLC)
形狀
powder
顏色
white to very dark brown
溶解度
DMSO: 2 mg/mL, clear (warmed)
儲存溫度
2-8°C
SMILES 字串
[nH]1c2c(nc1COCC)c(nc3c2cccc3)N
InChI
1S/C13H14N4O/c1-2-18-7-10-16-11-8-5-3-4-6-9(8)15-13(14)12(11)17-10/h3-6H,2,7H2,1H3,(H2,14,15)(H,16,17)
InChI 密鑰
DEVCLHVFELRPIU-UHFFFAOYSA-N
相關類別
1 of 4
本產品 | SML2235 | SML0376 | SML2495 |
|---|---|---|---|
| assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) |
| form powder | form powder | form powder | form powder |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C |
| solubility DMSO: 2 mg/mL, clear (warmed) | solubility DMSO: 2 mg/mL, clear | solubility DMSO: >2 mg/mL (warmed) | solubility DMSO: 2 mg/mL, clear |
| color white to very dark brown | color white to beige | color light yellow to light brown | color white to gray-brown |
生化／生理作用
CL097 is an imidazoquinoline (IMDQ) derivative (IQD) with dual toll-like receptor 7 & 8 (TLR7 & TLR8; TLR7/8) agonist activity. CL097 is commonly employed in the concentration range from 0.5 μg/mL to 45 μg/mL for stimulating cell surface TLR7/8 in cultures and is reported to be a stronger TLR7 ligand than CL075.
Imidazoquinoline (IMDQ) derivative (IQD) with dual toll-like receptor 7 & 8 (TLR7 & TLR8; TLR7/8) agonist activity. A stronger TLR7 ligand than CL075.
儲存類別代碼
13 - Non Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Jueqi Chen et al.
Nature, 564(7734), 71-76 (2018-11-30)
The NLRP3 inflammasome, which has been linked to human inflammatory diseases, is activated by diverse stimuli. How these stimuli activate NLRP3 is unknown. Here we show that different NLRP3 stimuli lead to disassembly of the trans-Golgi network (TGN). NLRP3 is
Zhikuan Zhang et al.
Cell reports, 25(12), 3371-3381 (2018-12-20)
Toll-like receptor 7 (TLR7) is an innate immune receptor for single-stranded RNA (ssRNA) and has important roles in infectious diseases. We previously reported that TLR7 shows synergistic activation in response to two ligands, guanosine and ssRNA. However, the specific ssRNA
Susanne Maria Ziegler et al.
Journal of reproductive immunology, 128, 30-37 (2018-06-11)
During pregnancy the maternal immune system has to develop tolerance towards the developing fetus. These changes in maternal immunity can result in increased severity of certain infections, but also in amelioration of autoimmune diseases. Pregnancy-related hormones have been suggested to
Masaaki Okamoto et al.
The Journal of biological chemistry, 293(48), 18585-18600 (2018-10-05)
The innate immune system is important for the efficacy of vaccines, but excessive innate immune responses can cause adverse reactions after vaccination. Extracellular vesicles (EVs) are enriched in the blood and can deliver functional RNAs, such as microRNAs (miRNAs), to
Xinqiang Hong et al.
Chinese journal of cancer research = Chung-kuo yen cheng yen chiu, 30(2), 197-208 (2018-06-05)
The aim of the present study was to investigate the effects of 5-fluorouracil (5-Fu) and oxaliplatin on the function and activation pathways of mouse dendritic cells (DCs), and to clarify whether 5-Fu/oxaliplatin combined with the CD1d-MC38/α-galactosylceramide (α-GC) tumor vaccine exhibits
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