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Merck

T7883

甲氧苄啶

≥98.5%

同義詞:

2,4-二氨基-5-(3,4,5-三甲氧基苄基)嘧啶, NSC 106568

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經驗公式(希爾表示法):
C14H18N4O3
CAS 編號:
分子量::
290.32
UNSPSC Code:
51285203
NACRES:
NA.85
PubChem Substance ID:
EC Number:
212-006-2
Beilstein/REAXYS Number:
625127
MDL number:

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產品名稱

甲氧苄啶, ≥98.5%

InChI key

IEDVJHCEMCRBQM-UHFFFAOYSA-N

InChI

1S/C14H18N4O3/c1-19-10-5-8(6-11(20-2)12(10)21-3)4-9-7-17-14(16)18-13(9)15/h5-7H,4H2,1-3H3,(H4,15,16,17,18)

SMILES string

COc1cc(Cc2cnc(N)nc2N)cc(OC)c1OC

assay

≥98.5%

form

powder

storage condition

(Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.)

color

white to light yellow

antibiotic activity spectrum

Gram-negative bacteria
Gram-positive bacteria
mycobacteria

mode of action

DNA synthesis | interferes
enzyme | inhibits

storage temp.

2-8°C

Quality Level

Gene Information

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本產品
92131469841692505
mode of action

DNA synthesis | interferes, enzyme | inhibits

mode of action

DNA synthesis | interferes, enzyme | inhibits

mode of action

DNA synthesis | interferes, enzyme | inhibits

mode of action

-

antibiotic activity spectrum

Gram-negative bacteria, mycobacteria, Gram-positive bacteria

antibiotic activity spectrum

Gram-negative bacteria, Gram-positive bacteria, mycobacteria

antibiotic activity spectrum

Gram-negative bacteria, Gram-positive bacteria, mycoplasma

antibiotic activity spectrum

-

Quality Level

200

Quality Level

200

Quality Level

100

Quality Level

-

assay

≥98.5%

assay

≥99.0% (HPLC)

assay

-

assay

-

form

powder

form

powder

form

-

form

-

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

-

Application

主要作为抗细菌剂。 二氢叶酸还原酶抑制活性和原核酶选择性。
甲氧苄啶是最主要的抗细菌剂。 它有二氢叶酸还原酶抑制活性和原核酶选择性。 它被用来治疗尿道感染,轻度急性前列腺炎,复发性膀胱炎,怀孕期间无症状菌尿和呼吸道感染。[1]

Biochem/physiol Actions

甲氧苄啶和磺胺甲恶唑结合,通过阻碍核苷酸合成,干扰细菌细胞叶酸细胞代谢。 甲氧苄啶和二氢叶酸还原酶结合,抑制二氢叶酸(DHF)和四氢叶酸(THF)还原。THF是胸腺嘧啶合成途径基本前体,干扰该途径,抑制细菌DNA合成。[1]

General description

化学结构:嘧啶

Other Notes

保持容器密闭,置于干燥通风处。置于干燥处。

Packaging

5G,25G,100G

pictograms

Health hazardExclamation mark

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral - Repr. 2

存儲類別/等級

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


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分析證明 (COA)

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Ariel Gilad et al.
Nature communications, 11(1), 1744-1744 (2020-04-10)
Association areas in neocortex encode novel stimulus-outcome relationships, but the principles of their engagement during task learning remain elusive. Using chronic wide-field calcium imaging, we reveal two phases of spatiotemporal refinement of layer 2/3 cortical activity in mice learning whisker-based
Mira Rakic-Martinez et al.
Applied and environmental microbiology, 77(24), 8714-8721 (2011-10-18)
Listeria monocytogenes is a leading agent for severe food-borne illness and death in the United States and other nations. Even though drug resistance has not yet threatened therapeutic interventions for listeriosis, selective pressure associated with exposure to antibiotics and disinfectants
Crystal Y Chen et al.
PLoS pathogens, 5(4), e1000392-e1000392 (2009-04-22)
The role of CD8 T cells in anti-tuberculosis immunity in humans remains unknown, and studies of CD8 T cell-mediated protection against tuberculosis in mice have yielded controversial results. Unlike mice, humans and nonhuman primates share a number of important features
Kate S Baker et al.
The Lancet. Infectious diseases, 15(8), 913-921 (2015-05-06)
Shigellosis is an acute, severe bacterial colitis that, in high-income countries, is typically associated with travel to high-risk regions (Africa, Asia, and Latin America). Since the 1970s, shigellosis has also been reported as a sexually transmitted infection in men who
E Van Duijkeren et al.
Journal of veterinary pharmacology and therapeutics, 17(1), 64-73 (1994-02-01)
The indications for use, side-effects, and pharmacokinetic parameters of trimethoprim, sulfonamides and their combinations in the horse are reviewed. Trimethoprim/sulfonamide (TMPS) combinations are used for the treatment of various diseases caused by gram-positive and gram-negative bacteria, including infections of the

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Biofiles 評論癌症研究的創新技術,反映出癌症的複雜性。

Cancer research innovations address the complexity of the disease, providing advanced technologies for varied applications.

Questions

1–5 of 5 Questions  
  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf

      Helpful?

  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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  3. Is it soluable in water or dmso and at what concentration should I use it?

    1 answer
    1. This material is practically insoluble in water at 0.4 mg/mL Additional solvents include the following:
      DMSO at 50 mg/mL
      methanol at 12 mg/mL
      chloroform at 18 mg/mL
      propyleneglycol at 25 mg/mL
      benzyl alcohol at 72 mg/mL
      dimethylacetamide at 138 mg/mL

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  4. Is Trimethoprim stable in solution?

    1 answer
    1. Triemethoprim in a solution of 52% N,N dimethylacetamide:48% propylene glycol at 50 mg/ml is stable when stored at 25° C. There is only a 10% degradation of trimethoprim under these conditions after 885 days.

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  5. What is the Department of Transportation shipping information for this product?

    1 answer
    1. Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.

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