MAPK10
mitogen-activated protein kinase 10
Synonyms:
JNK3, JNK3A, PRKM10, SAPK1b, p493F12, p54bSAPK
Species:
Human MAPK10 (5602), Mouse Mapk10 (26414), Rat Mapk10 (25272), Horse MAPK10 (100052608), Domestic Rabbit MAPK10 (100337999), domestic guinea pig Mapk10 (100718766), Zebrafish mapk10 (569698), sheep MAPK10 (101120665), dog MAPK10 (478464), domestic cat MAPK10 (101101463) ...More
UniProtKB ID:
Gene ID:
- Human(5602) Summary: The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This protein is a neuronal-specific form of c-Jun N-terminal kinases (JNKs). Through its phosphorylation and nuclear localization, this kinase plays regulatory roles in the signaling pathways during neuronal apoptosis. Beta-arrestin 2, a receptor-regulated MAP kinase scaffold protein, is found to interact with, and stimulate the phosphorylation of this kinase by MAP kinase kinase 4 (MKK4). Cyclin-dependent kianse 5 can phosphorylate, and inhibit the activity of this kinase, which may be important in preventing neuronal apoptosis. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
- Mouse(26414) mitogen-activated protein kinase 10
- Rat(25272) mitogen activated protein kinase 10
- Horse(100052608) mitogen-activated protein kinase 10
- Domestic Rabbit(100337999) mitogen-activated protein kinase 10
- domestic guinea pig(100718766) mitogen-activated protein kinase 10
- Zebrafish(569698) mitogen-activated protein kinase 10
- sheep(101120665) mitogen-activated protein kinase 10
- dog(478464) mitogen-activated protein kinase 10
- domestic cat(101101463) mitogen-activated protein kinase 10
- naked mole-rat(101712980) mitogen-activated protein kinase 10
- cow(537631) mitogen-activated protein kinase 10
- chicken(422592) mitogen-activated protein kinase 10
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Antibodies
Product Number
Description
Species Reactivity
Application
ANTI-MAPK10 antibody produced in mouse, clone 3A3-1A8, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
western blot
western blot
Anti-JNK3 Antibody, clone 2O10P2, Rabbit Monoclonal, ,
Species Reactivity
human, rat
Application
western blot
Monoclonal Anti-MAPK10 antibody produced in mouse, clone 3B9, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
western blot
western blot
Anti-Mapk10 Antibody Produced In Rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunofluorescence
western blot
western blot
Anti-MAPK10 antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
western blot
western blot
Small Molecule - Inhibitor
Proteins
Product Number
Description
Species
JNK3/SAPK1b Protein, active, 10 µg, Active, N-terminal His6 tagged, recombinant, full length human JNK3/SAPK1b, for use in Kinase Assays.,
Species
human
JNK3/SAPK1b Protein, inactive, 50 g, Unactive, N-terminal His6-tagged recombinant human JNK3/SAPK1b, for use in Kinase Assays.,
Species
human
esiRNA
Product Number
Description
Species