155195

N,O-Bis(trimethylsilyl)trifluoroacetamide

≥99%

• Synonym(s): BSTFA
• Linear Formula: CF₃C[=NSi(CH₃)₃]OSi(CH₃)₃
• CAS Number: 25561-30-2
• Molecular Weight: 257.40
• Beilstein: 2050024
• EC Number: 247-103-9
• MDL number: MFCD00008269
• PubChem Substance ID: 24849493
• NACRES: NA.22

Properties

• grade: synthesis grade
• Quality Level: 200
• Assay: ≥99%
• form: liquid
• refractive index: n20/D 1.384 (lit.)
• bp: 45-50 °C/14 mmHg (lit.)
• density: 0.969 g/mL at 25 °C (lit.)
• SMILES string: C[Si](C)(C)O\C(=N\[Si](C)(C)C)C(F)(F)F
• InChI: 1S/C8H18F3NOSi2/c1-14(2,3)12-7(8(9,10)11)13-15(4,5)6/h1-6H3/b12-7+
• InChI key: XCOBLONWWXQEBS-KPKJPENVSA-N

Description

General description

N,O-Bis(trimethylsilyl)trifluoroacetamide is an organosilicon reagent for trimethylsilylation, deprotection, dehydrogenation, allylic alkylation, nitronate formation, and Claisen rearrangement.

Application

N,O-Bis(trimethylsilyl)trifluoroacetamide can be used as a derivatization reagent for the determination of the estrogens estrone and 17α-ethinylestradiol by gas chromatography-mass spectrometry.

Safety Information

• Pictograms: GHS02,GHS07
• Signal Word: Warning
• Hazard Statements: H226 - H315 - H319
• Precautionary Statements: P210 - P233 - P240 - P241 - P303 + P361 + P353 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Flam. Liq. 3 - Skin Irrit. 2
• Storage Class Code: 3 - Flammable liquids
• WGK: WGK 3
• Flash Point(F): 93.2 °F
• Flash Point(C): 34 °C
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves