D1069

Desloratadine

powder, ≥98% (HPLC)

• Synonym(s): 8-Chloro-6,11-dihydro-11-(4-piperidinylidene)-5H- benzo[5,6]cyclohepta[1,2,b]pyridine, Clarinex^®, NSC 675447
• Empirical Formula (Hill Notation): C₁₉H₁₉ClN₂
• CAS Number: 100643-71-8
• Molecular Weight: 310.82
• MDL number: MFCD00871949
• UNSPSC Code: 12352200
• PubChem Substance ID: 329798668
• NACRES: NA.32

Properties

• assay: ≥98% (HPLC)
• form: powder
• solubility: DMSO: >10 mg/mL
• storage temp.: 2-8°C
• SMILES string: Clc1ccc2c(CCc3cccnc3\C2=C4\CCNCC4)c1
• InChI: 1S/C19H19ClN2/c20-16-5-6-17-15(12-16)4-3-14-2-1-9-22-19(14)18(17)13-7-10-21-11-8-13/h1-2,5-6,9,12,21H,3-4,7-8,10-11H2
• InChI key: JAUOIFJMECXRGI-UHFFFAOYSA-N
• Gene Information: human ... HRH1(3269)

Description

Application

Desloratadine has been used to test its effect on embryoid body development in in vitro gastrulation model of P19C5 stem cells.[1] It has also been used as an antihistamine mimic in rats[2] and to treat lung cancer (A549) and glioblastoma (U87) cells in various cellular studies.[3]

Biochem/physiol Actions

A non-sedating H₁-receptor antagonist, free from antimuscarinic/anticholinergic effects. It has novel antiallergic and anti-inflammatory effects.

Desloratadine is a selective and nonsedating histamine H1 receptor antagonist, an active metabolite of loratadine (Claritin), used to relieve hay fever and allergy symptoms with less drowsiness than other antihistamines; does not significantly inhibits cardiac K+ channels at clinically achievable blood levels. Free from antimuscarinic/anticholinergic effects.

Legal Information

Clarinex is a registered trademark of Schering Corp.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 1
• flash_point_f: 390.2 °F - Pensky-Martens closed cup
• flash_point_c: 199 °C - Pensky-Martens closed cup